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AIRE 抗体 (N-Term)

This anti-AIRE antibody is a 兔 多克隆 antibody detecting AIRE in WB. Suitable for 人, 大鼠, 犬, 马, Cow 和 Pig. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2779776
发货至: 中国

Quick Overview for AIRE 抗体 (N-Term) (ABIN2779776)

抗原

See all AIRE 抗体
AIRE (Autoimmune Regulator (AIRE))

适用

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  • 1
人, 大鼠, 犬, 马, Cow, Pig

宿主

  • 50
  • 7
  • 1
  • 1

克隆类型

  • 57
  • 1
多克隆

标记

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  • 1
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This AIRE antibody is un-conjugated

应用范围

  • 44
  • 27
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  • 1
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Western Blotting (WB)
  • 抗原表位

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    N-Term

    序列

    DFWRVLFKDY NLERYGRLQP ILDSFPKDVD LSQPRKGRKP PAVPKALVPP

    预测反应

    Cow: 79%, Dog: 92%, Horse: 86%, Human: 100%, Pig: 93%, Rat: 79%

    产品特性

    This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Protein A purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 545 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: "AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix." in: Molecular immunology, Vol. 43, Issue 4, pp. 335-45, (2005) (PubMed).

  • 抗原

    AIRE (Autoimmune Regulator (AIRE))

    别名

    AIRE

    背景

    AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
    Alias Symbols: APS1, APSI, PGA1, AIRE1, APECED
    Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
    Protein Size: 545

    分子量

    58 kDa

    基因ID

    326

    NCBI登录号

    NM_000383, NP_000374

    UniProt

    O43918

    途径

    Chromatin Binding
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