(1 reference)-
- 抗原 See all PITX2 抗体
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PITX2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- EFTDSPESRK EAASSKFFPR QHPGANEKDK SQQGKNEDVG AEDPSKKKRQ
- 预测反应
- Horse: 86%, Human: 100%, Mouse: 93%
- 产品特性
- This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2
- Top Product
- Discover our top product PITX2 Primary Antibody
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anti-Paired-Like Homeodomain 2 (PITX2) (AA 40-154) antibody
PITX2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (N-Term) antibodyPITX2 适用: 人, 大鼠, 小鼠, Pig, 兔, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-271) antibodyPITX2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (C-Term) antibodyPITX2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 20-69) antibodyPITX2 适用: 人, 小鼠, Pig, Cow, 猴, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 122-151) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) antibodyPITX2 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 317 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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- 抗原
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
- 别名
- PITX2 (PITX2 产品)
- 别名
- ARP1 antibody, Brx1 antibody, IDG2 antibody, IGDS antibody, IGDS2 antibody, IHG2 antibody, IRID2 antibody, Otlx2 antibody, PTX2 antibody, RGS antibody, RIEG antibody, RIEG1 antibody, RS antibody, 9430085M16Rik antibody, Brx1a antibody, Brx1b antibody, Munc30 antibody, Pitx2a antibody, Pitx2b antibody, Pitx2c antibody, Pitx2cbeta antibody, Ptx2 antibody, Rieg antibody, pitx2a antibody, pitx2c antibody, zgc:110508 antibody, XPtx2b antibody, xPtx2 antibody, xpitx2 antibody, arp1 antibody, brx1 antibody, idg2 antibody, igds antibody, igds2 antibody, ihg2 antibody, irid2 antibody, otlx2 antibody, pitx2-A antibody, ptx2 antibody, rgs antibody, rieg antibody, rieg1 antibody, pitx-2 antibody, pitx2 antibody, paired like homeodomain 2 antibody, paired-like homeodomain transcription factor 2 antibody, paired-like homeodomain 2 antibody, paired like homeodomain 2 S homeolog antibody, paired like homeodomain 2 L homeolog antibody, PITX2 antibody, Pitx2 antibody, pitx2 antibody, pitx2.S antibody, pitx2.L antibody
- 背景
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The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
Protein Size: 317 - 分子量
- 35 kDa
- 基因ID
- 5308
- NCBI登录号
- NM_153426, NP_700475
- UniProt
- Q99697
- 途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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