PITX2 抗体 (N-Term)
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北京 101111
Quick Overview for PITX2 抗体 (N-Term) (ABIN2779637)
抗原
See all PITX2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PESRKEAASS
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预测反应
- Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%
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产品特性
- This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2
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anti-Paired-Like Homeodomain 2 (PITX2) (AA 40-154) antibody
PITX2 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (N-Term) antibodyPITX2 适用: 人, 大鼠, 小鼠, Pig, 兔, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-271) antibodyPITX2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 20-69) antibodyPITX2 适用: 人, 小鼠, Pig, Cow, 猴, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 122-151) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) antibodyPITX2 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-100) antibodyPITX2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 317 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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: "PITX2 gain-of-function induced defects in mouse forelimb development." in: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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- PITX2 (Paired-Like Homeodomain 2 (PITX2))
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别名
- PITX2
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背景
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The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
Protein Size: 317 -
分子量
- 35 kDa
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基因ID
- 5308
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NCBI登录号
- NM_153426, NP_700475
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UniProt
- Q99697
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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