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GLI1 抗体 (C-Term)

Cited in 8+ publications. The 兔多克隆 anti-GLI1 antibody (ABIN2779593) specifically detects GLI1 in WB. The antibody is reactive with 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔和 Cow samples.

WB Suggested Anti-GLI1 Antibody Titration: 1. (GLI1 抗体 (C-Term))

Host: Rabbit Target Name: GLI1 Sample Tissue: Human Jurkat Antibody Dilution: 1. (GLI1 抗体 (C-Term))

Host: Rabbit Target Name: GLI1 Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 5. (GLI1 抗体 (C-Term))

Host: Rabbit Target Name: GLI1 Sample Type: HepG2 Whole Cell lysates Antibody Dilution: 0. (GLI1 抗体 (C-Term))

5 images

(8 references)

产品编号 ABIN2779593

发货至: 中国

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Quick Overview for GLI1 抗体 (C-Term) (ABIN2779593)

抗原

See all GLI1 抗体

GLI1 (Zinc Finger Protein GLI1 (GLI1))

适用

人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow

宿主

兔

克隆类型

多克隆

标记

This GLI1 antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product GLI1 Primary Antibody

抗原表位
16

5

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1

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1

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1
C-Term

序列

TNPSCGHPEV GRLGGGPALY PPPEGQVCNP LDSLDLDNTQ LDFVAILDEP

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

产品特性

This is a rabbit polyclonal antibody against GLI1. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Protein A purified

免疫原

The immunogen is a synthetic peptide directed towards the C terminal region of human GLI1
anti-Zinc Finger Protein GLI1 (GLI1) (AA 601-700) antibody
GLI1 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, FACS, IF (cc), IHC (p), ICC, IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) (AA 284-449) antibody
GLI1 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 1B9F8 unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) (AA 805-820) antibody
GLI1 适用: 小鼠 WB, ELISA, IHC, IF, FM 宿主: 兔 Polyclonal unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) (AA 200-300) antibody
GLI1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) (AA 401-500) antibody
GLI1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G11 unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) antibody
GLI1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB5550 unconjugated Recombinant Antibody

anti-Zinc Finger Protein GLI1 (GLI1) (C-Term) antibody
GLI1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) (AA 805-820) antibody
GLI1 适用: 小鼠 WB, ELISA, IF, FM 宿主: 兔 Polyclonal unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) (AA 921-1106) antibody
GLI1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Zinc Finger Protein GLI1 (GLI1) (AA 196-230) antibody
GLI1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB54395 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 1106 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bosco-Clément, Zhang, Chen, Zhou, Li, Mikami, Hirata, Yagui-Beltran, Lui, Do, Cheng, Tseng, Choi, Fang, Kim, Yue, Wang, Zheng, Fujii, Mann, Jablons, He: "Targeting Gli transcription activation by small molecule suppresses tumor growth." in: Oncogene, Vol. 33, Issue 16, pp. 2087-97, (2014) (PubMed).

Pandolfi, Montagnani, Penachioni, Vinci, Olivito, Borgognoni, Stecca: "WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function." in: Oncogene, Vol. 32, Issue 40, pp. 4737-47, (2013) (PubMed).

Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Chai: "Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice." in: Human molecular genetics, Vol. 23, Issue 1, pp. 182-93, (2013) (PubMed).

Ortega, Cases, Merchán, Kozyraki, Clemente, de Castro: "Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development." in: Glia, Vol. 60, Issue 6, pp. 851-66, (2012) (PubMed).

Ferruzzi, Mennillo, De Rosa, Giordano, Rossi, Benedetti, Magrini, Pericot Mohr, Miragliotta, Magnoni, Mori, Thomas, Tunici, Bakker: "In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines." in: International journal of cancer. Journal international du cancer, Vol. 131, Issue 2, pp. E33-44, (2012) (PubMed).

Maitah, Ali, Ahmad, Gadgeel, Sarkar: "Up-regulation of sonic hedgehog contributes to TGF-?1-induced epithelial to mesenchymal transition in NSCLC cells." in: PLoS ONE, Vol. 6, Issue 1, pp. e16068, (2011) (PubMed).

Schiapparelli, Shahi, Enguita-Germán, Johnsen, Kogner, Lázcoz, Castresana: "Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells." in: Cancer letters, Vol. 310, Issue 2, pp. 222-31, (2011) (PubMed).

Yoshimura, Kawate, Takeda: "Signaling through the primary cilium affects glial cell survival under a stressed environment." in: Glia, Vol. 59, Issue 2, pp. 333-44, (2010) (PubMed).
抗原

GLI1 (Zinc Finger Protein GLI1 (GLI1))

别名

GLI1

背景

GLI1 is a protein which is a member of the Kruppel family of zinc finger proteins. The function of this gene has not been determined, however, it may play a role in normal development gene transcription. Mouse mutation studies indicate possible involvement in human foregut malformation.
Alias Symbols: GLI
Protein Interaction Partner: TRIM42, GCC1, PRKAA2, VHL, FEM1B, CDK4, UBC, MYC, ITCH, NUMB, SUFU, RAI1, XBP1, HDAC2, HDAC1, STK36, DYRK1A, ZIC2, ZIC1, Sin3a, Shh, SAP18, Su(fu), Pias1,
Protein Size: 1106

分子量

118 kDa

基因ID

2735

NCBI登录号

NM_005269, NP_005260

UniProt

P08151

途径

Hedgehog Signaling, Dopaminergic Neurogenesis