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BRCA1 抗体 (N-Term)

Name: BRCA1 抗体 (N-Term)
SKU: ABIN2779333
Availability: OutOfStock

BRCA1 适用: 人, 大鼠, 马, 犬, 兔 WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-BRCA1 Antibody Titration: 0. (BRCA1 抗体 (N-Term))

Rabbit Anti-BRCA1 Antibody Catalog Number: ARP30434_P050 Formalin Fixed Paraffin Embedded Tissue: Human Lymph Node Tissue Observed Staining: Cytoplasm Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0. (BRCA1 抗体 (N-Term))

IHC

2 images

产品编号 ABIN2779333

发货至: 中国

Datasheet as PDF

抗原 See all BRCA1 抗体

BRCA1 (Breast Cancer 1 (BRCA1))
抗原表位
21

18

15

15

14

11

10

8

8

7

6

5

5

4

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
188

35

25

3

1

1
人, 大鼠, 马, 犬, 兔
宿主
160

34

2
兔
Compatible Secondaries
克隆类型
164

32
多克隆
标记
89

18

9

7

7

7

7

7

7

7

3

3

3

3

3

2

2

2

2

2

2

2

2
This BRCA1 antibody is un-conjugated
应用范围
123

67

42

41

39

37

27

22

21

12

11

10

9

9

3

2

2

2

1

1
Western Blotting (WB)

序列

DLSALRVEEV QNVINAMQKI LECPICLELI KEPVSTKCDH IFCKFCMLKL

预测反应

Dog: 92%, Horse: 85%, Human: 100%, Rabbit: 85%, Rat: 77%

产品特性

This is a rabbit polyclonal antibody against BRCA1. It was validated on Western Blot.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human BRCA1

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BRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

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BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

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BRCA1 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6C6D2 unconjugated

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BRCA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1661-1863) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) antibody
BRCA1 适用: 人, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

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BRCA1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibody
BRCA1 适用: 人, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibody
BRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 680 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

BRCA1 (Breast Cancer 1 (BRCA1))

别名

BRCA1 (BRCA1 产品)

别名

BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody

背景

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
Alias Symbols: BRCAI, BRCC1, IRIS, PSCP, RNF53, PNCA4, BROVCA1, PPP1R53
Protein Interaction Partner: RAD50, MED17, RAD51, YAP3, HDA3, SSN3, BEM4, GYP5, YAF9, HDAC2, MSH6, BAP1, SUPT5H, POLR2A, NPR1, NUP53, MET18, CDC21, MLP1, CTK1, MSH2, BACH1, DAN1, TMA22, BBC1, RPB4, SPT4, YGR053C, ATE1, YBP2, SLI15, RAD16, XRS2, RAD55, BUR2, BRIP1, ESR1, BECN1, HIST1H
Protein Size: 680

分子量

76 kDa

基因ID

672

NCBI登录号

NM_007298, NP_009229

UniProt

P38398

途径

Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus