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DFFA 抗体 (N-Term)

Name: DFFA 抗体 (N-Term)
SKU: ABIN2779329
Availability: OutOfStock

DFFA 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-DFFA Antibody Titration: 5. (DFFA 抗体 (N-Term))

1 image

产品编号 ABIN2779329

发货至: 中国

Datasheet as PDF

抗原 See all DFFA 抗体

DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
抗原表位
15

14

9

8

6

6

5

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
N-Term

适用

人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马
宿主
75

9

1
兔
Compatible Secondaries
克隆类型
77

8
多克隆
标记
61

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1
This DFFA antibody is un-conjugated
应用范围
82

30

15

14

13

13

12

10

6

6

3

2

1

1

1

1
Western Blotting (WB)

序列

MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL

预测反应

Cow: 92%, Dog: 83%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 83%, Rat: 92%

产品特性

This is a rabbit polyclonal antibody against DFFA. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Protein A purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human DFFA

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anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 1-331) antibody
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DFFA 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

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DFFA 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2B10C8 unconjugated

anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 19-262) antibody
DFFA 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) antibody
DFFA 适用: 人, 猴 WB, IF 宿主: 小鼠 Monoclonal 3F12 unconjugated

anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (C-Term) antibody
DFFA 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 331 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

别名

DFFA (DFFA 产品)

别名

DFF-45 antibody, DFF1 antibody, ICAD antibody, A330085O09Rik antibody, DFF35 antibody, Dff45 antibody, ICAD-L antibody, ICAD-S antibody, DFFA antibody, zgc:92229 antibody, DNA fragmentation factor subunit alpha antibody, DNA fragmentation factor, alpha subunit antibody, DNA fragmentation factor, 45kDa, alpha polypeptide antibody, DNA fragmentation factor, alpha polypeptide antibody, DFFA antibody, Dffa antibody, dffa antibody

背景

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DFF-45, DFF1, Ion ChannelAD, ICAD
Protein Interaction Partner: DFFB, UBC, TUBB, ATG3, ISOC1, BZW2, MAT2B, FERMT2, TUBA1A, CNBP, RPS6KA3, PPP5C, PFAS, MAT2A, EIF6, GAPDH, EIF5, CTPS1, CKB, GZMB, CASP7, CASP3, GZMM, TOM1L2, SEPT5, YWHAZ, YWHAG, PRKAA2, STRN4, NECAB2, CIDEB, EWSR1, NAP1L5, TMBIM4, USP15, HERC1, MCC, BAK
Protein Size: 331

分子量

37 kDa

基因ID

1676

NCBI登录号

NM_004401, NP_004392

UniProt

O00273

途径

Apoptosis, Caspase Cascade in Apoptosis