DFFA 抗体 (N-Term)
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北京 101111
Quick Overview for DFFA 抗体 (N-Term) (ABIN2779329)
抗原
See all DFFA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- DFFA Antibody - N-terminal region
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序列
- MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL
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预测反应
- Cow: 92%, Dog: 83%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 83%, Rat: 92%
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产品特性
- This is a rabbit polyclonal antibody against DFFA. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human DFFA
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anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 1-331) antibody
DFFA 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 51-305) antibodyDFFA 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 179-331) antibodyDFFA 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2B10C8 unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 2-21) antibodyDFFA 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 1-331) antibodyDFFA 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) antibodyKD Validated DFFA 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4810 unconjugated Recombinant Antibody
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 1-331) antibodyDFFA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 231-331) antibodyDFFA 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3A11 unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 19-262) antibodyDFFA 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 271-331) antibodyDFFA 适用: 人 IHC, IF (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8099047
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
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别名
- DFFA
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背景
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Targeted Subunit: alpha
Background Information: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: DNA fragmentation factor, 45 kDa, alpha polypeptide
Alternative Symbols: DFF1, ICAD, DFF-45
Protein Name: DNA fragmentation factor subunit alpha
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分子量
- 37kDa
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基因ID
- 1676
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NCBI登录号
- NP_004392
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UniProt
- O00273
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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