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SSB 抗体 (N-Term)

This anti-SSB antibody is a 兔 多克隆 antibody detecting SSB in WB 和 IHC. Suitable for 人, 小鼠, 大鼠, 犬, 马, 兔, Cow 和 豚鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2778846
发货至: 中国

Quick Overview for SSB 抗体 (N-Term) (ABIN2778846)

抗原

See all SSB 抗体
SSB (Sjogren Syndrome Antigen B (SSB))

适用

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  • 19
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  • 1
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  • 1
人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠

宿主

  • 78
  • 12
  • 5

克隆类型

  • 85
  • 10
多克隆

标记

  • 55
  • 6
  • 6
  • 5
  • 2
  • 2
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  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
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  • 1
This SSB antibody is un-conjugated

应用范围

  • 47
  • 36
  • 26
  • 15
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  • 12
  • 7
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  • 3
  • 2
  • 2
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  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 15
    • 10
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    序列

    ISEDKTKIRR SPSKPLPEVT DEYKNDVKNR SVYIKGFPTD ATLDDIKEWL

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

    产品特性

    This is a rabbit polyclonal antibody against SSB. It was validated on Western Blot and immunohistochemistry.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human SSB
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 408 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Teplova, Yuan, Phan, Malinina, Ilin, Teplov, Patel: "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen." in: Molecular cell, Vol. 21, Issue 1, pp. 75-85, (2006) (PubMed).

  • 抗原

    SSB (Sjogren Syndrome Antigen B (SSB))

    别名

    SSB

    背景

    SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE, MIM 152700) (Teplova et al., 2006).[supplied by OMIM].
    Alias Symbols: La, LARP3
    Protein Interaction Partner: HUWE1, UBC, MDM2, LIN28A, BMI1, SUZ12, RNF2, rev, NPLOC4, DNM1L, UBA2, ANP32A, VBP1, RABGGTA, PPP2CA, KARS, CTTN, TARDBP, SOX2, HMGA1, ARFGEF1, NCL, GZMH, CSNK2B, CSNK2A1, HCVgp1, CBX6, SPIB, IL7R, IFIT3, FN1, SMURF1, BARD1, PAXIP1, APP, TROVE2, XIAP, CAN
    Protein Size: 408

    分子量

    45 kDa

    基因ID

    6741

    NCBI登录号

    NM_003142, NP_003133

    UniProt

    P05455
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