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SMN1 抗体 (N-Term)

This anti-SMN1 antibody is a 兔 多克隆 antibody detecting SMN1 in WB. Suitable for 人, 小鼠, 大鼠, 犬, Pig, 兔, 豚鼠 和 马.
产品编号 ABIN2778671
发货至: 中国

Quick Overview for SMN1 抗体 (N-Term) (ABIN2778671)

抗原

See all SMN1 抗体
SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

适用

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人, 小鼠, 大鼠, 犬, Pig, 兔, 豚鼠, 马

宿主

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克隆类型

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多克隆

标记

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This SMN1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    序列

    KAVASFKHAL KNGDICETSG KPKTTPKRKP AKKNKSQKKN TAASLQQWKV

    预测反应

    Dog: 100%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 85%, Rat: 92%

    产品特性

    This is a rabbit polyclonal antibody against SMN1. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human SMN1
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 262 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

    别名

    SMN1

    背景

    SMN1 localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein.This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy, mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants are produced by this gene.
    Alias Symbols: BCD541, SMA, SMA1, SMA2, SMA3, SMA4, SMA@, SMN, SMNT, T-BCD541, SMN2
    Protein Interaction Partner: COPA, RNF2, BMI1, KDM1A, SMN1, RN7SL1, UBC, HDAC11, MIB1, GEMIN4, DICER1, DDX20, PAN2, RBFOX2, HNRNPUL1, IQCB1, UBL4A, SMN2, NOS2, vpr, GEMIN2, SRP68, SRP54, SRP19, SRP9, RNU2-1, RNU1-1, GEMIN5, MDC1, RBM25, COIL, SRSF5, HSPB1, CUL3, DDAH2, MAST2, SMC5, R
    Protein Size: 262

    分子量

    28 kDa

    基因ID

    6606

    NCBI登录号

    NM_022874, NP_075012

    UniProt

    Q16637

    途径

    Ribonucleoprotein Complex Subunit Organization
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