PHD1 抗体 (Middle Region)
(1 reference)Quick Overview for PHD1 抗体 (Middle Region) (ABIN2778438)
抗原
See all PHD1 (EGLN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- AVLDGSELSY FGQEGMTEVQ CGKVAFQFQC SSDSTNGTGV QGGQIPELIF
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预测反应
- Dog: 85%, Human: 100%
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产品特性
- This is a rabbit polyclonal antibody against EGLN2. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human EGLN2
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anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (AA 283-407) antibody
EGLN2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (AA 58-107) antibodyEGLN2 适用: 人, Cow, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (AA 150-250) antibodyEGLN2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (AA 1-407) antibodyEGLN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G3 unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (AA 194-221) antibodyEGLN2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22708 unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (C-Term) antibodyEGLN2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (N-Term) antibodyEGLN2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (AA 281-315) antibodyEGLN2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 马, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (N-Term) antibodyEGLN2 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2) (N-Term) antibodyEGLN2 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 407 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death." in: Oncogene, Vol. 28, Issue 45, pp. 4009-21, (2009) (PubMed).
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: "Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death." in: Oncogene, Vol. 28, Issue 45, pp. 4009-21, (2009) (PubMed).
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- PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))
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别名
- EGLN2
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背景
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The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. EGLN2 encodes an enzyme responsible for this posttranslational modification. Alternative splicing of EGLN2 results in three transcript variants encoding different isoforms. The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alias Symbols: DKFZp434E026, EIT6, HIFPH1, HPH-3, PHD1, HPH-1, HIF-PH1
Protein Interaction Partner: SRPK2, CEP192, IKBKG, FAM46A, EPAS1, A2M, MAGEA11, SIAH2, LPP, WTIP, AJUBA, LIMD1, TRIP6, SPRY2, PRPF19, EGLN3, EGLN2, HIF1A, HIF3A, MOB4, POLR2A,
Protein Size: 407 -
分子量
- 44 kDa
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基因ID
- 112398
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NCBI登录号
- NM_053046, NP_444274
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UniProt
- Q96KS0
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis
抗原
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