Claudin 16 抗体 (C-Term)
(2 references)Quick Overview for Claudin 16 抗体 (C-Term) (ABIN2778049)
抗原
See all Claudin 16 (CLDN16) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- FLAGAVLTCC LYLFKDVGPE RNYPYSLRKA YSAAGVSMAK SYSAPRTETA
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预测反应
- Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 93%, Rat: 86%
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产品特性
- This is a rabbit polyclonal antibody against CLDN16. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN16
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anti-Claudin 16 (CLDN16) (AA 1-73) antibody
CLDN16 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-Claudin 16 (CLDN16) (AA 1-73) antibodyCLDN16 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Claudin 16 (CLDN16) (AA 6-33), (N-Term) antibodyCLDN16 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB30098 unconjugated
anti-Claudin 16 (CLDN16) (AA 13-41), (N-Term) antibodyCLDN16 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Claudin 16 (CLDN16) (AA 6-33) antibodyCLDN16 适用: 人 WB, FACS, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Claudin 16 (CLDN16) (C-Term) antibodyCLDN16 适用: 人, 小鼠, Cow, 犬, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Claudin 16 (CLDN16) (AA 50-150) antibodyCLDN16 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Claudin 16 (CLDN16) (C-Term) antibodyCLDN16 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 305 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Claudin-19 and the barrier properties of the human retinal pigment epithelium." in: Investigative ophthalmology & visual science, Vol. 52, Issue 3, pp. 1392-403, (2011) (PubMed).
: "MicroRNA-204/211 alters epithelial physiology." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 5, pp. 1552-71, (2010) (PubMed).
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: "Claudin-19 and the barrier properties of the human retinal pigment epithelium." in: Investigative ophthalmology & visual science, Vol. 52, Issue 3, pp. 1392-403, (2011) (PubMed).
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- Claudin 16 (CLDN16)
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别名
- CLDN16
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背景
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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-16, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in the corresponding gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HOMG3, PCLN1
Protein Interaction Partner: APP, TJP1,
Protein Size: 305 -
分子量
- 34 kDa
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基因ID
- 10686
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NCBI登录号
- NM_006580, NP_006571
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UniProt
- Q9Y5I7
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途径
- Hepatitis C
抗原
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