PML 抗体 (C-Term)
Quick Overview for PML 抗体 (C-Term) (ABIN2777721)
抗原
See all PML 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- EGPSTLRVLD ENLADPQAED RPLVFFDLKI DNETQKISQL AAVNRESKFR
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特异性
- Isoform 1, 9, 10 and 11 specific
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预测反应
- Cow: 100%, Dog: 92%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 100%, Pig: 92%, Rabbit: 92%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against PML. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human PML
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anti-Promyelocytic Leukemia (PML) (AA 411-510) antibody
PML 适用: 人 WB, IF, ELISA, PLA 宿主: 小鼠 Monoclonal 1D12 unconjugated
anti-Promyelocytic Leukemia (PML) (N-Term) antibodyPML 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 470-499), (Sumoylation Site) antibodyPML 适用: 人 WB, IHC, IF, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 300-600) antibodyPML 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 411-510) antibodyPML 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 2B10 unconjugated
anti-Promyelocytic Leukemia (PML) (C-Term) antibodyPML 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 470-499), (Sumoylation Site) antibodyPML 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB2570 unconjugated
anti-Promyelocytic Leukemia (PML) (N-Term) antibodyPML 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 588-637) antibodyPML 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Promyelocytic Leukemia (PML) (AA 59-239) antibodyPML 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 540 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- PML (Promyelocytic Leukemia (PML))
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别名
- PML
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背景
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PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus.
Alias Symbols: MYL, PP8675, RNF71, TRIM19
Protein Interaction Partner: RPL11, RPL5, SUMO1, UBC, TP53, SUMO2, SUMO3, MDM2, RNF4, EGFR, NCOA2, SP100, DAXX, MAPK7, HDAC1, ATXN1, ATRX, ASF1A, EHMT2, HIRA, HTT, H3F3A, ATF7IP, PML, JAK1, EIF4E, GLIS2, UBE2I, smt3, HDAC11, HDAC6, LMNA, RNF111, CDK6, CDK2, CDK1, CASP8AP2, RBX1, SH3G
Protein Size: 540 -
分子量
- 59 kDa
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基因ID
- 5371
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UniProt
- P29590, A4VCI9
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途径
- p53 Pathway, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
抗原
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