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NOTCH4 抗体 (Middle Region)

Name: NOTCH4 抗体 (Middle Region)
SKU: ABIN2777550
Availability: OutOfStock

This anti-NOTCH4 antibody is a 兔多克隆 antibody detecting NOTCH4 in WB 和 IHC. Suitable for 人, 大鼠, Cow, 马, 豚鼠和 Pig. This Primary Antibody has been cited in 3+ publications.

Host: Rabbit Target Name: NOTCH4 Sample Tissue: Human Lung Tumor Antibody Dilution: 1. (NOTCH4 抗体 (Middle Region))

WB Suggested Anti-NOTCH4 Antibody Titration: 0. (NOTCH4 抗体 (Middle Region))

Immunohistochemistry with Human Breast tissue at an antibody concentration of 5. (NOTCH4 抗体 (Middle Region))

IHC

4 images

(3 references)

产品编号 ABIN2777550

发货至: 中国

Quick Overview for NOTCH4 抗体 (Middle Region) (ABIN2777550)

抗原

See all NOTCH4 抗体

NOTCH4 (Notch 4 (NOTCH4))

适用

人, 大鼠, Cow, 马, 豚鼠, Pig

宿主

兔

克隆类型

多克隆

标记

This NOTCH4 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product NOTCH4 Primary Antibody

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Middle Region

序列

LLLGLGAARE LRDQAGLAPA DVAHQRNHWD LLTLLEGAGP PEARHKATPG

预测反应

Cow: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Pig: 100%, Rat: 93%

产品特性

This is a rabbit polyclonal antibody against NOTCH4. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human NOTCH4
anti-Notch 4 (NOTCH4) (AA 1715-2001) antibody
NOTCH4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) antibody
NOTCH4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) (AA 371-420) antibody
NOTCH4 适用: 人, Cow, 马, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) (AA 1261-1273) antibody
Verified NOTCH4 适用: 人, 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) (AA 1824-2003) antibody
NOTCH4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) (Middle Region) antibody
NOTCH4 适用: 人, Cow, 马, 豚鼠, Pig, 犬, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) (Cleaved-Val1432) antibody
NOTCH4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) (C-Term) antibody
NOTCH4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Notch 4 (NOTCH4) (AA 1819-1851), (C-Term) antibody
NOTCH4 适用: 人 WB 宿主: 兔 Polyclonal RB52895 unconjugated

anti-Notch 4 (NOTCH4) antibody
NOTCH4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 589 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bhat, Sun, Weger, Raouf: "Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells." in: Stem cells and development, Vol. 25, Issue 7, pp. 522-9, (2016) (PubMed).

Sun, Klauzinska, Lake, Lee, Santopietro, Raafat, Salomon, Callahan, Artavanis-Tsakonas: "Trp53 regulates Notch 4 signaling through Mdm2." in: Journal of cell science, Vol. 124, Issue Pt 7, pp. 1067-76, (2011) (PubMed).

Sugaya, Sasanuma, Nohata, Kimura, Fukagawa, Nakamura, Ando, Inoko, Ikemura, Mita: "Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3." in: Gene, Vol. 189, Issue 2, pp. 235-44, (1997) (PubMed).
抗原

NOTCH4 (Notch 4 (NOTCH4))

别名

NOTCH4

背景

NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases.
Alias Symbols: INT3, NOTCH4
Protein Interaction Partner: EGFL7, Dlg4, SMAD4, SMAD3, SMAD2, TCEB1, UBC, TP53, MDM2, MAML3, MAML2, FBXW7, MAML1, DLL4, PSEN2, NOTCH4, RBPJ, PSEN1,
Protein Size: 589

分子量

61 kDa

基因ID

4855

途径

Notch Signaling