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TFAM 抗体 (N-Term)

Name: TFAM 抗体 (N-Term)
SKU: ABIN2777277
Availability: OutOfStock

This anti-TFAM antibody is a 兔多克隆 antibody detecting TFAM in WB. Suitable for 人, 小鼠, 兔, Cow, 犬, 豚鼠, 马和 Pig. This Primary Antibody has been cited in 10+ publications.

Western Blotting (WB) image for anti-Transcription Factor A, Mitochondrial (TFAM) (N-Term) antibody (ABIN2777277) (TFAM 抗体 (N-Term))

TFAM antibody - N-terminal region validated by WB using bEND3 cell lysate at lane1:10 ug, lane2:20 ug. (TFAM 抗体 (N-Term))

Lanes: Lane 1 and 2: HepG2 cell lysate Lane 3 and 4: Hep3B cell lysate Lane 5 and 6: K562 cell lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Secondary Antibody Dilution: 1:1000 Gene Name: TFAM Submitted by: Anonymous (TFAM 抗体 (N-Term))

WB Suggested Anti-TFAM Antibody Titration: 0. (TFAM 抗体 (N-Term))

6 images

(10 references)

产品编号 ABIN2777277

发货至: 中国

Quick Overview for TFAM 抗体 (N-Term) (ABIN2777277)

抗原

See all TFAM 抗体

TFAM (Transcription Factor A, Mitochondrial (TFAM))

适用

人, 小鼠, 兔, Cow, 犬, 豚鼠, 马, Pig

宿主

兔

克隆类型

多克隆

标记

This TFAM antibody is un-conjugated

应用范围

Western Blotting (WB)

抗原表位
15

9

9

8

5

5

4

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term

序列

AKTTELIRRI AQRWRELPDS KKKIYQDAYR AEWQVYKEEI SRFKEQLTPS

预测反应

Cow: 92%, Dog: 83%, Guinea Pig: 75%, Horse: 92%, Human: 100%, Mouse: 75%, Pig: 92%, Rabbit: 83%

产品特性

This is a rabbit polyclonal antibody against Transcription Factor AntibodiesAM. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human TFAM
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 43-243) antibody
TFAM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) (AA 1-220) antibody
TFAM 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) (AA 1-246) antibody
TFAM 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) antibody
KO Validated TFAM 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) (AA 227-246), (C-Term) antibody
TFAM 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) (AA 216-246), (C-Term) antibody
TFAM 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB27631 unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) (AA 1-246) antibody
TFAM 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) antibody
TFAM 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Monoclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) (AA 216-246) antibody
TFAM 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Transcription Factor A, Mitochondrial (TFAM) (AA 214-241), (N-Term) antibody
TFAM 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 246 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Ogasawara, Liu, Pelicano, Hammoudi, Croce, Keating, Huang: "Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53." in: Mitochondrion, Vol. 31, pp. 33-39, (2016) (PubMed).

Kemper, Stirone, Krause, Duckles, Procaccio: "Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection." in: European journal of pharmacology, Vol. 723, pp. 322-9, (2014) (PubMed).

Vettor, Valerio, Ragni, Trevellin, Granzotto, Olivieri, Tedesco, Ruocco, Fossati, Fabris, Serra, Carruba, Nisoli: "Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism." in: American journal of physiology. Endocrinology and metabolism, Vol. 306, Issue 5, pp. E519-28, (2014) (PubMed).

Kemper, Zhao, Duckles, Krause: "Endogenous ovarian hormones affect mitochondrial efficiency in cerebral endothelium via distinct regulation of PGC-1 isoforms." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 1, pp. 122-8, (2013) (PubMed).

Teodoro, Duarte, Gomes, Varela, Peixoto, Rolo, Palmeira: "Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation." in: Mitochondrion, Vol. 13, Issue 6, pp. 637-46, (2013) (PubMed).

Miyazaki, Iwasawa, Nakashima, Mori, Shigemoto, Nakamura, Katagiri, Takayanagi, Tanaka: "Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption." in: The Journal of biological chemistry, Vol. 287, Issue 45, pp. 37808-23, (2012) (PubMed).

Lu, Chen, Zhang, Wang, Luo, Huang: "ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction." in: Cell death & disease, Vol. 3, pp. e422, (2012) (PubMed).

Walters, Wallace: "Urea cycle gene expression is suppressed by PFOA treatment in rats." in: Toxicology letters, Vol. 197, Issue 1, pp. 46-50, (2010) (PubMed).

Walters, Bjork, Wallace: "Perfluorooctanoic acid stimulated mitochondrial biogenesis and gene transcription in rats." in: Toxicology, Vol. 264, Issue 1-2, pp. 10-5, (2009) (PubMed).

Shi, Burkart, Nicoloro, Czech, Straubhaar, Corvera: "Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells." in: The Journal of biological chemistry, Vol. 283, Issue 45, pp. 30658-67, (2008) (PubMed).
抗原

TFAM (Transcription Factor A, Mitochondrial (TFAM))

别名

TFAM

背景

The function remains unknown.This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.
Alias Symbols: TCF6, MtTF1, mtTFA, TCF6L1, TCF6L2, TCF6L3
Protein Interaction Partner: AGTRAP, FBXW11, ARL6IP1, NEDD1, PPP2R1A, GRSF1, UBC, MDM2, SUZ12, EED, PAN2, MYC, FN1, C1QBP, CAND1, COPS5, CUL3, ELAVL1, ICT1, TFB2M, TFB1M, PNP, NRF1,
Protein Size: 246

分子量

29 kDa

基因ID

7019

NCBI登录号

NM_003201, NP_003192

UniProt

Q00059

途径

Chromatin Binding