Leptin 抗体 (N-Term)
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北京 101111
Quick Overview for Leptin 抗体 (N-Term) (ABIN2776943)
抗原
See all Leptin (LEP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- LEP Antibody - N-terminal region
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序列
- MHWGTLCGFL WLWPYLFYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS
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预测反应
- Cow: 86%, Dog: 86%, Goat: 91%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 100%, Rabbit: 79%, Rat: 100%, Sheep: 91%
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产品特性
- This is a rabbit polyclonal antibody against LEP. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human LEP
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anti-Leptin (LEP) (AA 22-167) antibody
LEP 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 22-167) antibodyLEP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 17-100) antibodyLEP 适用: Cow WB, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 8-37) antibodyLEP 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 22-167) antibodyLEP 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 29-160) antibodyLEP 适用: Cow IHC 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 101-154) antibodyLEP 适用: 小鼠 FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 7-37), (N-Term) antibodyLEP 适用: 人 WB, FACS, IF, EIA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 22-167) antibodyLEP 适用: 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leptin (LEP) (AA 22-167) antibodyLEP 适用: 人 WB 宿主: 小鼠 Monoclonal C5 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41697-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs." in: Reproduction in domestic animals = Zuchthygiene, Vol. 52 Suppl 2, pp. 187-192, (2017) (PubMed).
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- Leptin (LEP)
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别名
- LEP
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背景
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Background Information: This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development.
Gene Name: leptin
Alternative Symbols: OB, OBS, LEPD
Protein Name: leptin
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分子量
- 19kDa
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基因ID
- 3952
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NCBI登录号
- NP_000221
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UniProt
- P41159
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途径
- JAK/STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
抗原
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