GAPVD1 抗体 (N-Term)
Quick Overview for GAPVD1 抗体 (N-Term) (ABIN2775423)
抗原
See all GAPVD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
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产品特性
- This is a rabbit polyclonal antibody against GAPVD1. It was validated on Western Blot and immunohistochemistry.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human GAPVD1
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anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 1-629) antibody
GAPVD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (N-Term) antibodyGAPVD1 适用: 人, 小鼠, 犬, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 182-231) antibodyGAPVD1 适用: 人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 马, 兔, Bat, 小鸡, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) (AA 1-260) antibodyGAPVD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) antibodyGAPVD1 适用: 小鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 1487 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
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别名
- GAPVD1
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背景
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GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
Alias Symbols: DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5
Protein Interaction Partner: UBC, FOXK1, LRRC47, SF3A1, HNRNPR, IQGAP1, CCDC6, NR3C1, YWHAB, COPS2, SIRT7, ELAVL1, VAV2, RAD21, Csnk1e, CBL,
Protein Size: 1487 -
分子量
- 166 kDa
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基因ID
- 26130
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NCBI登录号
- NM_015635, NP_056450
抗原
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