MCM4 抗体 (Middle Region)
Quick Overview for MCM4 抗体 (Middle Region) (ABIN2774884)
抗原
See all MCM4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- VYKTHIDVIH YRKTDAKRLH GLDEEAEQKL FSEKRVELLK ELSRKPDIYE
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
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产品特性
- This is a rabbit polyclonal antibody against MCM4. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human MCM4
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anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 1-863) antibody
MCM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 1-863) antibodyMCM4 适用: 人 WB, IHC (p), IF 宿主: 小鼠 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 2-141) antibodyMCM4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) antibodyMCM4 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 637-665) antibodyMCM4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 267-366) antibodyMCM4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (C-Term) antibodyMCM4 适用: 人, 小鼠, 大鼠, 兔, Cow, 豚鼠, 犬, 斑马鱼, Pig, 非洲爪蟾, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 97-146) antibodyMCM4 适用: 人, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 411-460) antibodyMCM4 适用: 人, 小鼠, 大鼠, 兔, Cow, 豚鼠, 犬, 马, 斑马鱼, 猴, Pig, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 80-129) antibodyMCM4 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 猴, Pig, 非洲爪蟾, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 863 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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别名
- MCM4
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背景
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The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. The MCM4 gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks.
Alias Symbols: CDC21, CDC54, hCdc21, P1-CDC21
Protein Interaction Partner: HUWE1, UBC, PCNA, SUMO2, FKBP5, MCMBP, MDM2, POLK, CLUH, NCKAP1, CAP1, CAP2, EIF3B, MCM2, KPNA3, PRMT1, FKBP4, MCM7, MCM6, FBXW4, FBXO46, ITGA4, CDC5L, gag-pol, ORC6, CCNA1, VCAM1, DBF4, CDC7, LIG4, MCM5, MCM3, DCTN2, SF3A1, UBD, NEDD8, TONSL, SIRT7, ASF1
Protein Size: 863 -
分子量
- 95 kDa
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基因ID
- 4173
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NCBI登录号
- NM_005914, NP_005905
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UniProt
- P33991
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
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