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FBXW2 抗体 (Middle Region)

FBXW2 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2774691
发货至: 中国
  • 抗原 See all FBXW2 抗体
    FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))
    抗原表位
    • 15
    • 6
    • 4
    • 1
    • 1
    Middle Region
    适用
    • 28
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼
    宿主
    • 26
    • 1
    • 1
    克隆类型
    • 28
    多克隆
    标记
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXW2 antibody is un-conjugated
    应用范围
    • 13
    • 13
    • 10
    • 9
    • 5
    • 3
    • 3
    Western Blotting (WB)
    序列
    SLISRWPLPE YRKSKRGSSF LAGEASWLNG LDGHNDTGLV FATSMPDHSI
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    产品特性
    This is a rabbit polyclonal antibody against FBXW2. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human FBXW2
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 454 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Van Rechem, Black, Abbas, Allen, Rinehart, Yuan, Dutta, Whetstine: "The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein." in: The Journal of biological chemistry, Vol. 286, Issue 35, pp. 30462-70, (2011) (PubMed).

  • 抗原
    FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))
    别名
    FBXW2 (FBXW2 产品)
    别名
    FBXW2 antibody, md6 antibody, fbw2 antibody, fwd2 antibody, MGC53244 antibody, FBW2 antibody, Fwd2 antibody, Md6 antibody, wu:fc72f10 antibody, zgc:110365 antibody, 2700071L08Rik antibody, MD6 antibody, F-box and WD repeat domain containing 2 antibody, F-box and WD repeat domain containing 2 L homeolog antibody, F-box and WD-40 domain protein 2 antibody, FBXW2 antibody, fbxw2 antibody, Fbxw2 antibody, fbxw2.L antibody
    背景
    F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. FBXW2 is the second identified member of the F-box family and contains multiple WD-40 repeats.F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
    Alias Symbols: FBW2, Fwd2, MGC117371, Md6
    Protein Interaction Partner: SKP1, FBXO6, CUL1, GNB2L1, GCM1, HSP90AA1, BTG2, BTG1, REST, RBX1, FBXW8, EP300, UBE2D2, CDC34,
    Protein Size: 454
    分子量
    51 kDa
    基因ID
    26190
    NCBI登录号
    NM_012164, NP_036296
    UniProt
    Q9UKT8
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