ZCCHC11 抗体 (Middle Region)
Quick Overview for ZCCHC11 抗体 (Middle Region) (ABIN2774235)
抗原
See all ZCCHC11 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- GSAQQQGDQS IRTRQSSECS ESPSYSPQPQ PFPQNSSQSA AITQPSSQPG
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against ZCCHC11. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human ZCCHC11
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anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-290) antibody
ZCCHC11 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Internal Region) antibodyZCCHC11 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1403-1452) antibodyZCCHC11 适用: 人, 犬, Cow, 豚鼠, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-309) antibodyZCCHC11 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (C-Term) antibodyVerified ZCCHC11 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Internal Region) antibodyVerified ZCCHC11 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1568-1600), (C-Term) antibodyZCCHC11 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51164 unconjugated
anti-Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (AA 1-309) antibodyZCCHC11 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 1645 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))
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别名
- ZCCHC11
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背景
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ZCCHC11 is the uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mRNA degradation.
Alias Symbols: PAPD3, TUT4
Protein Interaction Partner: UBC, MYC, TIFA, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL4B, CUL5, ELAVL1,
Protein Size: 1645 -
分子量
- 185 kDa
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基因ID
- 23318
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NCBI登录号
- NM_001009881, NP_001009881
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UniProt
- Q5TAX3
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途径
- Stem Cell Maintenance
抗原
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