ACE2 抗体 (Middle Region)
Quick Overview for ACE2 抗体 (Middle Region) (ABIN2774060)
抗原
See all ACE2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- FVTAPKNVSD IIPRTEVEKA IRMSRSRIND AFRLNDNSLE FLGIQPTLGP
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预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 86%, Rat: 93%
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产品特性
- This is a rabbit polyclonal antibody against ACE2. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human ACE2
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 805 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 9, pp. 1434-43, (2015) (PubMed).
: "
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ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 9, pp. 1434-43, (2015) (PubMed).
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- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
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别名
- ACE2
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背景
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ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This protein catalyzes the cleavage of angiotensin I into angiotensin 1-9. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ACEH, DKFZP434A014
Protein Interaction Partner: ACE2, AGT, CALM1, NTS, GHRL,
Protein Size: 805 -
分子量
- 89 kDa
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基因ID
- 59272
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NCBI登录号
- NM_021804, NP_068576
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UniProt
- Q9BYF1
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途径
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
抗原
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