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BHMT 抗体 (N-Term)

Cited in 3+ publications. This 兔 多克隆 anti-BHMT antibody specifically detects BHMT in WB 和 IHC. The antibody is reactive with 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow, 兔 和 斑马鱼 samples.
产品编号 ABIN2773785
发货至: 中国
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Quick Overview for BHMT 抗体 (N-Term) (ABIN2773785)

抗原

See all BHMT 抗体
BHMT (Betaine--Homocysteine S-Methyltransferase (BHMT))

适用

  • 44
  • 10
  • 9
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
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人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow, 兔, 斑马鱼

宿主

  • 37
  • 10
  • 1

克隆类型

  • 29
  • 19
多克隆

标记

  • 36
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
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This BHMT antibody is un-conjugated

应用范围

  • 45
  • 30
  • 17
  • 14
  • 8
  • 8
  • 7
  • 7
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    N-Term

    序列

    AVEHPEAVRQ LHREFLRAGS NVMQTFTFYA SEDKLENRGN YVLEKISGQE

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

    产品特性

    This is a rabbit polyclonal antibody against BHMT. It was validated on Western Blot and immunohistochemistry.

    纯化方法

    Protein A purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human BHMT
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 406 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Jiang, Hurt, Breen, Stabler, Allen, Orlicky, Maclean: "Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap." in: Biology open, Vol. 4, Issue 9, pp. 1154-62, (2015) (PubMed).

    Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

    Maclean, Jiang, Greiner, Allen, Stabler et al.: "Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine ..." in: Molecular genetics and metabolism, Vol. 105, Issue 3, pp. 395-403, (2012) (PubMed).

  • 抗原

    BHMT (Betaine--Homocysteine S-Methyltransferase (BHMT))

    别名

    BHMT

    背景

    BHMT is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in its gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.Betaine-homocysteine methyltransferase is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in BHMT could lead to hyperhomocyst(e)inemia,but such a defect has not yet been observed.
    Alias Symbols: BHMT1
    Protein Interaction Partner: BHMT, BBS4, BBS2, BBS1, ALG9, LAMTOR3,
    Protein Size: 406

    分子量

    45 kDa

    基因ID

    635

    NCBI登录号

    NM_001713, NP_001704

    UniProt

    Q93088

    途径

    Methionine Biosynthetic Process
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