ERCC1 抗体
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北京 101111
Quick Overview for ERCC1 抗体 (ABIN2763838)
抗原
See all ERCC1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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产品特性
- Excision Repair Cross Complementing protein-1, Nucleotide Excision Repair Protein,Recognizes a protein of 33-36 kDa, identified as the Excision Repair Cross Complementing (ERCC1). The mammalian ERCC1-encoded polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. The structure-specific ERCC1/XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV-induced lesions and bulky chemical adducts, and recombination repair of the very genotoxic interstrand cross-links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.
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纯化方法
- Antigen Immunoaffinity Purification
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免疫原
- Synthetic peptide derived from human ERCC1 protein
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亚型
- Ig Fraction
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anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (AA 151-250) antibody
ERCC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (AA 1-297) antibodyERCC1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 5A2D1 unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) antibodyKD Validated ERCC1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB1230 unconjugated Recombinant Antibody
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (AA 191-281) antibodyERCC1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERCC1-2318 unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (AA 151-297) antibodyERCC1 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1E5B3 unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (AA 1-120) antibodyERCC1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3F9E9 unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (AA 1-323) antibodyERCC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (AA 1-323) antibodyERCC1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (Internal Region) antibodyERCC1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross Complementing Polypeptide-1 (ERCC1) (Internal Region) antibodyERCC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- This antibody can be used for Western blotting (5-10 μg/mL) and immunohistochemistry on formalin/paraffin sections (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
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别名
- ERCC1 (DNA excision repair protein)
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UniProt
- P07992
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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