hCoV-OC43 Spike 抗体 (AA 15-344)
This 兔 多克隆 antibody specifically detects hCoV-OC43 Spike in ELISA, IF 和 WB. It exhibits reactivity toward Human Coronavirus OC43 (HCoV-OC43). It has been mentioned in 3+ publications
(3 references)
产品编号 ABIN2754654
发货至:
中国
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Quick Overview for hCoV-OC43 Spike 抗体 (AA 15-344) (ABIN2754654)
抗原
hCoV-OC43 Spike (HCoV-OC43 S)
(Coronavirus OC43 Spike Protein (HCoV-OC43 S))
适用
Human Coronavirus OC43 (HCoV-OC43)
宿主
兔
克隆类型
多克隆
标记
This hCoV-OC43 Spike antibody is un-conjugated
应用范围
ELISA, Immunofluorescence (IF), Western Blotting (WB)
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抗原表位
- AA 15-344
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纯化方法
- Caprylic Acid Ammonium Sulfate Precipitation
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免疫原
- Recombinant Human coronavirus OC43 Spike glycoprotein protein(15-344aa)
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亚型
- IgG
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C/-80 °C
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: "Efficient Human Cell Coexpression System and Its Application to the Production of Multiple Coronavirus Antigens." in: Advanced biology, Vol. 5, Issue 4, pp. e2000154, (2021) (PubMed).
: "Antibody Mediated Immunity to SARS-CoV-2 and Human Coronaviruses: Multiplex Beads Assay and Volumetric Absorptive Microsampling to Generate Immune Repertoire Cartography." in: Frontiers in immunology, Vol. 12, pp. 696370, (2021) (PubMed).
: "Kurarinone Inhibits HCoV-OC43 Infection by Impairing the Virus-Induced Autophagic Flux in MRC-5 Human Lung Cells." in: Journal of clinical medicine, Vol. 9, Issue 7, (2020) (PubMed).
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: "Efficient Human Cell Coexpression System and Its Application to the Production of Multiple Coronavirus Antigens." in: Advanced biology, Vol. 5, Issue 4, pp. e2000154, (2021) (PubMed).
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- hCoV-OC43 Spike (HCoV-OC43 S) (Coronavirus OC43 Spike Protein (HCoV-OC43 S))
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别名
- OC43 Spike Glycoprotein
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物质类
- Viral Protein
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背景
- S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
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UniProt
- P36334
抗原
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