电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

PDE4C 抗体 (C-Term)

This 兔 多克隆 antibody specifically detects PDE4C in WB, ELISA, IP, IF, IHC, ICC 和 CM. It exhibits reactivity toward 人, 小鼠 和 大鼠. It has been mentioned in 9+ publications
产品编号 ABIN2750931
发货至: 中国
Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for PDE4C 抗体 (C-Term) (ABIN2750931)

抗原

See all PDE4C 抗体
PDE4C (phosphodiesterase 4C, CAMP-Specific (PDE4C))

适用

  • 29
  • 11
  • 11
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 26
  • 3

克隆类型

  • 27
  • 2
多克隆

标记

  • 22
  • 2
  • 2
  • 1
  • 1
  • 1
This PDE4C antibody is un-conjugated

应用范围

  • 28
  • 18
  • 5
  • 4
  • 4
  • 4
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Confocal Microscopy (CM)
  • 抗原表位

    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    纯化方法

    Affinity Purified

    免疫原

    Synthetic cyclic carboxy-terminal peptide common to all PDE4C variants.

    亚型

    IgG
  • 限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.65 μg/μL
  • Cheng, Wu, He, Liu, Jia, Di, Ji: "siRNA-mediated silencing of phosphodiesterase 4B expression affects the production of cytokines in endotoxin-stimulated primary cultured microglia." in: Experimental and therapeutic medicine, Vol. 12, Issue 4, pp. 2257-2264, (2017) (PubMed).

    Ji, Di, He, Liu, Liu, Li, Zhang: "Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1914-22, (2016) (PubMed).

    Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

    Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

    Yougbaré, Boire, Roy, Lugnier, Rouseau: "NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production." in: Canadian journal of physiology and pharmacology, Vol. 91, Issue 5, pp. 353-61, (2014) (PubMed).

    Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

    Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

    Murray, Patel, Suda, Zhang, Thistlethwaite, Yuan, Insel: "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 1, pp. L294-303, (2007) (PubMed).

    Gallagher, Bacon, Odumeru, Gallagher, Fitzpatrick, Regan: "Valproate activates phosphodiesterase-mediated cAMP degradation: relevance to C6 glioma G1 phase progression." in: Neurotoxicology and teratology, Vol. 26, Issue 1, pp. 73-81, (2004) (PubMed).

  • 抗原

    PDE4C (phosphodiesterase 4C, CAMP-Specific (PDE4C))

    别名

    PDE4C

    UniProt

    Q08493

    途径

    Negative Regulation of Hormone Secretion, cAMP Metabolic Process
You are here: