CD79b 抗体 (APC)
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北京 101111
Quick Overview for CD79b 抗体 (APC) (ABIN2749136)
抗原
See all CD79b (CD79B) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD79b APC
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特异性
- The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.
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交叉反应 （详细）
- Human
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纯化方法
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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免疫原
- Fraction of Ig-associated molecules isolated from Ramos B cells
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亚型
- IgG1 kappa
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anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-159) antibody
CD79B 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 1-229) antibodyCD79B 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 4E10-2A10 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (C-Term) antibodyCD79B 适用: 人 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal B29-123 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibody (FITC)CD79B 适用: 人 FACS 宿主: 小鼠 Monoclonal CB3-1 FITC
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibody (PE)CD79B 适用: 人 FACS 宿主: 小鼠 Monoclonal CB3-1 PE
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-229) antibodyCD79B 适用: 人, 小鼠, 大鼠 WB, FACS, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 WB, FACS, IP, IHC (p) 宿主: 小鼠 Monoclonal CB3-1 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 30-160) antibodyCD79B 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2G3C1 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB8065 unconjugated
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应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
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限制
- 仅限研究用
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缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." in: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).
: "In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates." in: Molecular cancer therapeutics, Vol. 8, Issue 10, pp. 2937-46, (2009) (PubMed).
: "New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders." in: Journal of clinical pathology, Vol. 55, Issue 3, pp. 180-3, (2002) (PubMed).
: "CD79b expression in B-cell chronic lymphocytic leukemia." in: Haematologica, Vol. 85, Issue 5, pp. 556-7, (2000) (PubMed).
: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).
: "Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8522-6, (1992) (PubMed).
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: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." in: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).
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- CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
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别名
- CD79b
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背景
- CD79b molecule,CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR beta, Ig-beta, B29, IGB
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基因ID
- 974
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UniProt
- P40259
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途径
- BCR Signaling
抗原
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