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CD4 抗体 (FITC)

This anti-CD4 antibody is a 小鼠 单克隆 antibody detecting CD4 in FACS. Suitable for 大鼠. This Primary Antibody has been cited in 9+ publications.
Pubmed (9 references)
产品编号 ABIN2749064
发货至: 中国

Quick Overview for CD4 抗体 (FITC) (ABIN2749064)

抗原

See all CD4 抗体
CD4

适用

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大鼠

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小鼠

克隆类型

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单克隆

标记

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This CD4 antibody is conjugated to FITC

应用范围

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Flow Cytometry (FACS)

克隆位点

OX-35
Discover our top product CD4 Primary Antibody

  • 原理

    Anti-Rt CD4 FITC

    特异性

    The mouse monoclonal antibody OX-35 reacts with an extracellular epitope of rat CD4 transmembrane glycoprotein (55 kDa).

    交叉反应 （详细）

    Rat

    纯化方法

    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    免疫原

    MLR generated rat Th cells

    亚型

    IgG2a kappa
  • anti-CD4 (CD4) (AA 385-457) antibody
    anti-CD4 (CD4) (AA 385-457) antibody

    CD4 适用: 人, 小鼠, 大鼠, 小鸡, Pig FACS, WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

    anti-CD4 (CD4) antibody
    anti-CD4 (CD4) antibody

    CD4 适用: 人, 小鼠, 大鼠, 小鸡, 猴, 犬, Pig, 兔, Cat, Cow, 绵羊, 豚鼠, 山羊, 马, Avian, 驴, Hamster WB, IHC 宿主: 山羊 Polyclonal unconjugated

    anti-CD4 (CD4) (AA 231-330) antibody
    anti-CD4 (CD4) (AA 231-330) antibody

    CD4 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

    anti-CD4 (CD4) (N-Term) antibody
    anti-CD4 (CD4) (N-Term) antibody

    CD4 适用: 人 FACS, WB, MS 宿主: 小鼠 Monoclonal MEM-241 unconjugated

    anti-CD4 (CD4) (AA 301-400) antibody
    anti-CD4 (CD4) (AA 301-400) antibody

    CD4 适用: 人, 小鼠, 大鼠 FACS, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

    anti-CD4 (CD4) antibody
    anti-CD4 (CD4) antibody

    CD4 适用: 小鼠 FACS, IP, IHC (fro), ICC, Func 宿主: 大鼠 Monoclonal GK1-5 unconjugated

    anti-CD4 (CD4) (N-Term) antibody (FITC)
    anti-CD4 (CD4) (N-Term) antibody (FITC)

    CD4 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-241 FITC

    anti-CD4 (CD4) antibody (PE)
    anti-CD4 (CD4) antibody (PE)

    CD4 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal OX-35 PE

    anti-CD4 (CD4) (N-Term) antibody (PE)
    anti-CD4 (CD4) (N-Term) antibody (PE)

    CD4 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-241 PE

    anti-CD4 (CD4) (AA 26-200) antibody
    anti-CD4 (CD4) (AA 26-200) antibody

    CD4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

  • 应用备注

    Flow cytometry: Recommended dilution: 1-4 μg/mL.

    限制

    仅限研究用

  • 浓度

    0.5 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Viel, Lemarié, Benkirane, Paradis, Schiffrin: "Immune regulation and vascular inflammation in genetic hypertension." in: American journal of physiology. Heart and circulatory physiology, Vol. 298, Issue 3, pp. H938-44, (2010) (PubMed).

    Baba, Iwasaki, Maruoka, Suzuki, Tomaru, Ikeda, Yoshiki, Kasahara, Ishizu: "Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 2999-3006, (2008) (PubMed).

    Ramiro-Puig, Pérez-Cano, Ramos-Romero, Pérez-Berezo, Castellote, Permanyer, Franch, Izquierdo-Pulido, Castell: "Intestinal immune system of young rats influenced by cocoa-enriched diet." in: The Journal of nutritional biochemistry, Vol. 19, Issue 8, pp. 555-65, (2008) (PubMed).

    Baba, Ishizu, Iwasaki, Suzuki, Tomaru, Ikeda, Yoshiki, Kasahara: "CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype." in: Blood, Vol. 107, Issue 5, pp. 2004-12, (2006) (PubMed).

    Gelderman, Hultqvist, Holmberg, Olofsson, Holmdahl: "T cell surface redox levels determine T cell reactivity and arthritis susceptibility." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 34, pp. 12831-6, (2006) (PubMed).

    Yan, Devos, Yu, Xia, Rutgeerts, Goebels, Segers, Lin, Vandeputte, Waer: "Pathogenesis of autoimmunity after xenogeneic thymus transplantation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 5936-46, (2003) (PubMed).

    Tsuji, Kawaguchi, Wada, Nagoya, Inobe, Yamashita, Ishii, Uede: "Adenovirus-mediated in vivo B7-1 gene transfer induces anti-tumor immunity against pre-established primary tumor and pulmonary metastasis of rat osteosarcoma." in: Cancer gene therapy, Vol. 9, Issue 9, pp. 747-55, (2002) (PubMed).

    Salomon, Netzer, Wildbaum, Schif-Zuck, Maor, Karin: "Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 5, pp. 2685-93, (2002) (PubMed).

    Dragun, Lukitsch, Tullius, Qun, Park, Schneider, Luft, Haller: "Inhibition of intercellular adhesion molecule-1 with antisense deoxynucleotides prolongs renal isograft survival in the rat." in: Kidney international, Vol. 54, Issue 6, pp. 2113-22, (1999) (PubMed).

  • 抗原

    CD4

    别名

    CD4

    背景

    CD4 Molecule,CD4 (T4) is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1), IL-16 (binds to CD4 domain 3), human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin. Intracellular ligands: p56LckCD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus, CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).,T4/Leu-3, L3T4

    基因ID

    24932

    UniProt

    P05540

    途径

    TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
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