P-Selectin 抗体
(2 references)Quick Overview for P-Selectin 抗体 (ABIN2749032)
抗原
See all P-Selectin (SELP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Anti-Hu CD62P Purified Low Endotoxin
-
特异性
- The antibody AK4 recognizes an extracellular epitope of CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes, it is relocated to the plasma membrane upon activation.
-
交叉反应 （详细）
- Human, Non-Human Primates
-
纯化方法
- Purified by protein-A affinity chromatography.
-
纯度
- > 95 % (by SDS-PAGE)
-
内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
-
免疫原
- Human platelets
-
亚型
- IgG1 kappa
-
-
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 701-768) antibody
SELP 适用: 人, 大鼠, 小鼠, Pig WB, FACS, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 198-432) antibodySELP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 58-158) antibodySELP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibodySELP 适用: 人, Non-Human Primate WB, FACS, IP, ICC 宿主: 小鼠 Monoclonal AK4 unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 30-200) antibodySELP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 58-195) antibodySELP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibody (Biotin)SELP 适用: 人, Non-Human Primate WB, FACS, IP, ICC 宿主: 小鼠 Monoclonal AK4 Biotin
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (N-Term) antibodySELP 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 198-432) antibodySELP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C9 unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibodySELP 适用: 人, 猕猴 WB, FACS, IHC (fro), IF, IHC (p) 宿主: 小鼠 Monoclonal AK-6 unconjugated
-
-
应用备注
-
Functional application: Blocking.
Flow cytometry: Recommended dilution: 1.5 μg/mL. -
限制
- 仅限研究用
-
-
-
浓度
- 1 mg/mL
-
缓冲液
- Phosphate buffered saline (PBS), pH 7.4
-
储存条件
- 4 °C
-
储存方法
- Store at 2-8°C. Do not freeze.
-
-
-
: "Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets." in: British journal of haematology, Vol. 104, Issue 2, pp. 220-9, (1999) (PubMed).
: "Characterization of GMP-140 (P-selectin) as a circulating plasma protein." in: The Journal of experimental medicine, Vol. 175, Issue 4, pp. 1147-50, (1992) (PubMed).
-
: "Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets." in: British journal of haematology, Vol. 104, Issue 2, pp. 220-9, (1999) (PubMed).
-
- P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
-
别名
- CD62P
-
背景
- Selectin P,CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.,P-selectin, GMP140, SELP, PADGEM, GRMP, LECAM3, PSEL
-
基因ID
- 6403
-
UniProt
- P16109
抗原
-
