TNFRSF12A 抗体
(3 references)Quick Overview for TNFRSF12A 抗体 (ABIN2749025)
抗原
See all TNFRSF12A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD266 Purified Low Endotoxin
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特异性
- The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
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交叉反应 （详细）
- Human, Mouse
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
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免疫原
- human CD266-transfected P815 cells
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亚型
- IgG2b
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 28-80) antibody
TNFRSF12A 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5C9B4 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 24-126) antibodyTNFRSF12A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibodyTNFRSF12A 适用: 人, 小鼠 WB, FACS, IHC (fro) 宿主: 小鼠 Monoclonal ITEM-4 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibodyTNFRSF12A 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 7H8 unconjugated Recombinant Antibody
anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 104-118) antibodyTNFRSF12A 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 猴, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody (PE)TNFRSF12A 适用: 人, 小鼠 FACS 宿主: 小鼠 Monoclonal ITEM-4 PE
anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 28-129) antibodyTNFRSF12A 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1B6 unconjugated
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应用备注
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Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, (2012) (PubMed).
: "Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1593-605, (2010) (PubMed).
: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, (2002) (PubMed).
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: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, (2012) (PubMed).
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- TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
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别名
- CD266
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背景
- TNF receptor superfamily member 12A,CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.,TWEAKR, FN14, TNFRSF12A
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基因ID
- 51330
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UniProt
- Q9NP84
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途径
- Apoptosis, Regulation of Cell Size
抗原
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