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CD11b 抗体

Name: CD11b 抗体
Brand: antibodies-online
SKU: ABIN2749012
Availability: OutOfStock

ITGAM 适用: 人, Non-Human Primate FACS, IP, IHC (fro), ICC, Func 宿主: 小鼠 Monoclonal ICRF44 unconjugated

Flow cytometry surface staining pattern of human peripheral blood stained using anti-human CD11b (ICRF44) purified antibody (low endotoxin, concentration in sample 6 μg/mL) GAM APC. (CD11b 抗体)

FACS

Separation of human neutrophil granulocytes (red-filled) from CD11b negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD11b (ICRF44) purified antibody (low endotoxin, concentration in sample 6 μg/mL) GAM APC. (CD11b 抗体)

FACS

2 images

(3 references)

产品编号 ABIN2749012

发货至: 中国

Datasheet as PDF

抗原 See all CD11b (ITGAM) 抗体

CD11b (ITGAM) (Integrin alpha M (ITGAM))
适用
250

160

62

33

17

17

16

14

10

7

7

5

5

2

2

1
人, Non-Human Primate
宿主
131

102

95

4

1

1
小鼠
Compatible Secondaries
克隆类型
234

96

1
单克隆
标记
111

37

29

25

19

10

7

6

6

6

5

5

4

4

4

4

4

4

3

3

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This CD11b antibody is un-conjugated
应用范围
247

81

76

69

56

36

35

24

19

19

13

13

7

6

5

5

4

3

2

2

2

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Functional Studies (Func)

特异性

The mouse monoclonal antibody ICRF44 recognizes an extracellular epitope of CD11b (Mac-1alpha), a 165-170 kDa type 1 transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells.

交叉反应（详细）

Human, Non-Human Primates

纯化方法

Purified by protein-A affinity chromatography.

纯度

> 95 % (by SDS-PAGE)

内毒素水平

Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

免疫原

Rheumatoid synovial cells and human monocytes.

克隆位点

ICRF44

亚型

IgG1

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应用备注

Functional application: Blocking of granulocyte activation.
Flow cytometry: Recommended dilution: 1-12 μg/mL

限制

仅限研究用
浓度

1 mg/mL

缓冲液

Phosphate buffered saline (PBS), pH 7.4

储存液

Azide free

储存条件

4 °C

储存方法

Store at 2-8°C. Do not freeze.
Tieu, Lee, Sun, Lejeune, Recinos, Ju, Spratt, Guo, Milewicz, Tilton, Brasier: "An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice." in: The Journal of clinical investigation, Vol. 119, Issue 12, pp. 3637-51, (2009) (PubMed).

Masten, Olson, Tarleton, Rund, Schuyler, Mehran, Archibeque, Lipscomb: "Characterization of myeloid and plasmacytoid dendritic cells in human lung." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 11, pp. 7784-93, (2006) (PubMed).

Hua, Sakamoto, Nagaoka: "Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils." in: Journal of leukocyte biology, Vol. 71, Issue 4, pp. 632-40, (2002) (PubMed).
抗原

CD11b (ITGAM) (Integrin alpha M (ITGAM))

别名

CD11b (ITGAM 产品)

别名

CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody

背景

Integrin subunit alpha M,CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18), expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.,Mac-1, Integrin alpha M, ITGAM, CR3A, MO1A, MAC1A

基因ID

3684

UniProt

P11215

途径

Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation