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PDE4D 抗体

Cited in 25+ publications. The 兔 多克隆 anti-PDE4D antibody (ABIN2747152) specifically detects PDE4D in WB, ELISA, IHC, IP, ICC, IF 和 CM. The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN2747152
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for PDE4D 抗体 (ABIN2747152)

抗原

See all PDE4D 抗体
PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This PDE4D antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Confocal Microscopy (CM)
  • 纯化方法

    Affinity Purified

    免疫原

    Synthetic peptide selective for all PDE4D variants.

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.57 μg/μL
  • Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

    Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

    Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." in: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

    Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

    Dong, Guo, Ye, Hare: "Presynaptic inhibition by α2 receptor/adenylate cyclase/PDE4 complex at retinal rod bipolar synapse." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 28, pp. 9432-40, (2014) (PubMed).

    Wang, Zhang, Liu, Zhao, Zhang, Yuan, An, Li, Wang, Qin, Wilson, ODonnell, Zhang, Li: "RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects." in: British journal of pharmacology, Vol. 168, Issue 4, pp. 1001-14, (2013) (PubMed).

    Michalski, Kanaji, Liu, Nogel, Wang, Basma, Nakanishi, Sato, Gunji, Fahrid, Nelson, Muller, Holz, Magnussen, Rabe, Toews, Rennard: "Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4." in: American journal of respiratory cell and molecular biology, Vol. 47, Issue 6, pp. 729-37, (2013) (PubMed).

    Al-Tawashi, Jung, Liu, Su, Qin: "Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 14644-58, (2012) (PubMed).

    Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

    Genders, Bradley, Rattigan, Richards: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).

    Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

    Gregg, Steppan, Gonzalez, Champion, Phan, Nyhan, Shoukas, Hare, Barouch, Berkowitz: "β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation." in: Anesthesia and analgesia, Vol. 111, Issue 4, pp. 870-7, (2010) (PubMed).

    Zhang, Huang, Masood, Stolinski, Li, Zhang, Dlaboga, Jin, Conti, ODonnell: "Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 33, Issue 7, pp. 1611-23, (2008) (PubMed).

    Nomura-Furuwatari, Wakitani, Hashimoto, Imai, Ohta, Nakagawa, Nakao, Takayama, Manaka, Takaoka: "Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells." in: Journal of bone and mineral metabolism, Vol. 26, Issue 2, pp. 152-8, (2008) (PubMed).

    Fujita, Imaizumi, DSa, Zoghbi, Crescenzo, Hong, Musachio, Gee, Seidel, Green, Pike, Duman, Innis: "In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration." in: Synapse (New York, N.Y.), Vol. 61, Issue 2, pp. 78-86, (2007) (PubMed).

    Creighton, Zhu, Alexeyev, Stevens: "Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation." in: Journal of cell science, Vol. 121, Issue Pt 1, pp. 110-9, (2007) (PubMed).

    Baxendale, Fraser: "Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 495-508, (2006) (PubMed).

    Dlaboga, Hajjhussein, ODonnell: "Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram." in: Brain research, Vol. 1096, Issue 1, pp. 104-12, (2006) (PubMed).

    Terrin, Di Benedetto, Pertegato, Cheung, Baillie, Lynch, Elvassore, Prinz, Herberg, Houslay, Zaccolo: "PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases." in: The Journal of cell biology, Vol. 175, Issue 3, pp. 441-51, (2006) (PubMed).

    Wang, Deng, Bugaj-Gaweda, Kwan, Gunwaldsen, Leonard, Xin, Hu, Unterbeck, De Vivo: "Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7." in: Cellular signalling, Vol. 15, Issue 9, pp. 883-91, (2004) (PubMed).

  • 抗原

    PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

    别名

    PDE4D

    UniProt

    Q07343

    途径

    Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
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