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TEK 抗体 (Extracellular Domain)

TEK 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal tek2 unconjugated
产品编号 ABIN2745570
发货至: 中国
  • 抗原 See all TEK 抗体
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    抗原表位
    • 19
    • 19
    • 16
    • 11
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    适用
    • 135
    • 66
    • 49
    • 22
    • 4
    • 3
    宿主
    • 128
    • 16
    • 3
    • 2
    • 2
    小鼠
    克隆类型
    • 134
    • 17
    单克隆
    标记
    • 69
    • 10
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This TEK antibody is un-conjugated
    应用范围
    • 79
    • 58
    • 40
    • 40
    • 36
    • 26
    • 14
    • 13
    • 12
    • 8
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    特异性
    Native human TIE-2 in ELISA experiments and on the surface of different human cell types.
    交叉反应
    纯化方法
    Protein G purified.
    免疫原
    Recombinant human soluble extracellular domain of TIE-2.
    克隆位点
    Tek2
    亚型
    IgG1
    Top Product
    Discover our top product TEK Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL.
    浓度
    Lot specific
    缓冲液
    Lyophilized.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    有效期
    6 months
  • 抗原
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    别名
    TIE-2 (TEK 产品)
    别名
    TEK antibody, DKFZp469E064 antibody, AA517024 antibody, Cd202b antibody, Hyk antibody, Tie2 antibody, tie-2 antibody, CD202B antibody, TIE-2 antibody, TIE2 antibody, VMCM antibody, VMCM1 antibody, Tie-2 antibody, tie2 antibody, TEK receptor tyrosine kinase antibody, angiopoietin-1 receptor antibody, TEK tyrosine kinase, endothelial antibody, TEK antibody, LOC100408334 antibody, tek antibody, Tek antibody
    背景
    TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. It has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. It is required for normal angiogenesis and heart development during embryogenesis and for post-natal hematopoiesis. After birth, it activates or inhibits angiogenesis, depending on the context. It inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1 and ultimately to the stimulation of sprouting angiogenesis.
    UniProt
    Q02763
    途径
    RTK signaling, Growth Factor Binding
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