Podoplanin 抗体
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北京 101111
Quick Overview for Podoplanin 抗体 (ABIN2745557)
抗原
See all Podoplanin (PDPN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes mouse podoplanin.
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交叉反应
- 小鼠
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无交叉反应
- 人
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交叉反应 (详细)
- Does not cross-react with human podoplanin.
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纯化方法
- Protein G purified.
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免疫原
- Murine thymic stromal cell line.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL.
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浓度
- Lot specific
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缓冲液
- Lyophilized.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. -
有效期
- 6 months
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- Podoplanin (PDPN)
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别名
- Podoplanin
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背景
- Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
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途径
- Dicarboxylic Acid Transport
抗原
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