PLGF 抗体 (AA 206-221)
Quick Overview for PLGF 抗体 (AA 206-221) (ABIN2743614)
抗原
See all PLGF (PGF) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 206-221
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特异性
- Human PGF / PLGF
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纯化方法
- Immunoaffinity purified
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免疫原
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A synthetic peptide corresponding to a sequence at the C-terminus of human PLGF(206-221aa REKMKPERCGDAVPRR). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%), Cat (88%).
Type of Immunogen: Synthetic peptide -
亚型
- IgG
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应用备注
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Approved: WB (0.5 - 1 μg/mL)
Usage: Placental growth factor(PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1. -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Sterile distilled water
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浓度
- Lot specific
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缓冲液
- Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.
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- PLGF (PGF) (Placenta Growth Factor (PGF))
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别名
- PGF / PLGF
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背景
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Name/Gene ID: PGF
Family: PDGF
Synonyms: PGF, D12S1900, PGFL, PlGF-2, Placental growth factor, Placental growth factor-like, PLGF, Placenta growth factor, SHGC-10760 -
基因ID
- 5228
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途径
- VEGFR1 Specific Signals
抗原
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