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KEAP1 抗体

Name: KEAP1 抗体
SKU: ABIN2724101
Availability: OutOfStock

There are 11+ publications for this product available. The 小鼠单克隆 anti-KEAP1 antibody is suitable to detect KEAP1 in samples from 人和小鼠. It has been validated for WB, IHC 和 FACS.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KEAP1 (Right lane) cDNA for 48 hrs and lysed. (KEAP1 抗体)

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-KEAP1 mouse monoclonal antibody. (KEAP1 抗体)

IHC

HEK293T cells transfected with either RC202189 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-KEAP1 antibody (ABIN2453954), and then analyzed by flow cytometry. (KEAP1 抗体)

FACS

3 images

(11 references)

产品编号 ABIN2724101

发货至: 中国

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Quick Overview for KEAP1 抗体 (ABIN2724101)

抗原

See all KEAP1 抗体

KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

适用

人, 小鼠

宿主

小鼠

克隆类型

单克隆

标记

This KEAP1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

克隆位点

1B4

Discover our top product KEAP1 Primary Antibody

产品特性

Homo sapiens kelch-like ECH-associated protein 1 (KEAP1), transcript variant 1

纯化方法

Purified from mouse ascites fluids by affinity chromatography

免疫原

Full length human recombinnt protein of human KEAP1(NP_987096) produced in HEK293T cell.

亚型

IgG1
anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) antibody
KEAP1 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 1B4 unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibody
KEAP1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7G4B10 unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibody
KEAP1 适用: 人, 小鼠 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1F10B6 unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 380-624) antibody
KEAP1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (C-Term) antibody
KEAP1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 65-160) antibody
KEAP1 适用: 人, 小鼠, 大鼠, Pig, 兔 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 327-624) antibody
KEAP1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 1-286) antibody
KEAP1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 41-53) antibody
Verified KEAP1 适用: 人 IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) antibody
KD Validated KEAP1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB495 unconjugated

应用备注

WB 1:500~2000, IHC 1:150, FLOW 1:100,

说明

The concentration of the product may vary between diferrent lots.

限制

仅限研究用
状态

Liquid

浓度

0.5-1.0 mg/mL

缓冲液

PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C
Mulvaney, Matson, Siesser, Tamir, Goldfarb, Jacobs, Cloer, Harrison, Vaziri, Cook, Major: "Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate." in: The Journal of biological chemistry, Vol. 291, Issue 45, pp. 23719-23733, (2016) (PubMed).

Caner, Sen Turk, Baris, Cetin, Tepeli, Hacioglu, Sari, Zencir, Dogu, Bagci, Keskin: "MYD88 Expression and L265P Mutation in Mature B-Cell Non-Hodgkin Lymphomas." in: Genetic testing and molecular biomarkers, Vol. 19, Issue 7, pp. 372-8, (2015) (PubMed).

Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: "Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers." in: PLoS ONE, Vol. 9, Issue 2, pp. e88168, (2014) (PubMed).

Michaeloudes, Mercado, Clarke, Bhavsar, Adcock, Barnes, Chung: "Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 10, pp. 4913-20, (2014) (PubMed).

Zhao, Duan, Yuan, Quan, Yang, Xi: "A reusable localized surface plasmon resonance biosensor for quantitative detection of serum squamous cell carcinoma antigen in cervical cancer patients based on silver nanoparticles array." in: International journal of nanomedicine, Vol. 9, pp. 1097-104, (2014) (PubMed).

Vieceli Dalla Sega, Zambonin, Fiorentini, Rizzo, Caliceti, Landi, Hrelia, Prata: "Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 806-14, (2014) (PubMed).

Rondini, Fang, Runge-Morris, Kocarek: "Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 42, Issue 3, pp. 361-8, (2014) (PubMed).

Adebiyi, Soni, John, Yang: "Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells." in: Experimental cell research, Vol. 324, Issue 1, pp. 92-104, (2014) (PubMed).

Barnett, Liebl, Seymour, Gillen, Lim, Larock, Davies, Schulz, Nizet, Teasdale, Walker: "The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication." in: Cell host & microbe, Vol. 14, Issue 6, pp. 675-82, (2013) (PubMed).

Tanaka, Tanaka, Harada, Kohda, Matsumura, Shimamoto, Sawabe, Marunaka, Kuwabara, Takahashi, Ito, Nakahari: "A PKG inhibitor increases Ca(2+)-regulated exocytosis in guinea pig antral mucous cells: cAMP accumulation via PDE2A inhibition." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 304, Issue 9, pp. G773-80, (2013) (PubMed).

Ramdzan, Polling, Chia, Ng, Ormsby, Croft, Purcell, Bogoyevitch, Ng, Gleeson, Hatters: "Tracking protein aggregation and mislocalization in cells with flow cytometry." in: Nature methods, Vol. 9, Issue 5, pp. 467-70, (2012) (PubMed).
抗原

KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

别名

KEAP1

背景

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

分子量

69.5 kDa

基因ID

9817

NCBI登录号

NM_203500

HGNC

9817

途径

Maintenance of Protein Location