SMAD4 抗体
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北京 101111
Quick Overview for SMAD4 抗体 (ABIN272224)
抗原
See all SMAD4 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Smad4 protein. (region surrounding Leu43)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-SMAD Family Member 4 (SMAD4) (N-Term) antibody
SMAD4 适用: 人 WB, IP, CUT&RUN 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 1-552) antibodySMAD4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 255-284) antibodySMAD4 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB14714 unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodySMAD4 适用: 人, 小鼠 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 4G1C6 unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 400-428), (C-Term) antibodySMAD4 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB20720 unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 40-120) antibodySMAD4 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) (AA 27-195) antibodySMAD4 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodyKD Validated SMAD4 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB975 unconjugated Recombinant Antibody
anti-SMAD Family Member 4 (SMAD4) (AA 400-428) antibodySMAD4 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-SMAD Family Member 4 (SMAD4) antibodySMAD4 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 3A1 unconjugated
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应用备注
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ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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: "Proteomic analysis of differentially expressed proteins in vitamin C-treated AGS cells." in: BMC biochemistry, Vol. 14, pp. 24, (2014) (PubMed).
: "PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis." in: Cell death & disease, Vol. 4, pp. e811, (2013) (PubMed).
: "Smad4 disruption accelerates keratinocyte reepithelialization in murine cutaneous wound repair." in: Histochemistry and cell biology, Vol. 138, Issue 4, pp. 573-82, (2012) (PubMed).
: "MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB." in: FEBS letters, Vol. 586, Issue 19, pp. 3263-70, (2012) (PubMed).
: "A minute pancreatic ductal adenocarcinoma with lipomatous pseudohypertrophy of the pancreas." in: JOP : Journal of the pancreas, Vol. 12, Issue 5, pp. 464-8, (2011) (PubMed).
: "Transforming growth factor-?/Smad signaling function in the aortopathies." in: Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular, Vol. 26, Issue 3, pp. 393-403, (2011) (PubMed).
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- SMAD4 (SMAD Family Member 4 (SMAD4))
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别名
- SMAD4
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背景
- Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.Synonyms: DPC4, Deletion target in pancreatic carcinoma 4, MAD homolog 4, MADH4, Mothers against DPP homolog 4, Mothers against decapentaplegic homolog 4, SMAD 4, SMAD family member 4, SMAD-4
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分子量
- approx. 60 kDa
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基因ID
- 4089
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NCBI登录号
- NP_005350
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UniProt
- Q13485
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途径
- Cell Division Cycle, Chromatin Binding, Autophagy
抗原
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