TLE4 抗体
Quick Overview for TLE4 抗体 (ABIN272213)
抗原
See all TLE4 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of TLE4 protein. (region surrounding His190)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 1-773) antibody
TLE4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 284-394) antibodyTLE4 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) antibodyTLE4 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 161-210) antibodyTLE4 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 215-264) antibodyTLE4 适用: 人, 大鼠, 小鼠, 小鸡, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (Internal Region) antibodyTLE4 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (N-Term) antibodyTLE4 适用: 人, 大鼠, 小鼠, 小鸡, Cow, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (Center) antibodyTLE4 适用: 人, 大鼠, 小鼠, 小鸡 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (N-Term) antibodyTLE4 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- TLE4 (Transducin-like Enhancer Protein 4 (TLE4))
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别名
- TLE4
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背景
- The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is up-regulated, and TLE2 and TLE4 are down-regulated.Synonyms: GRG4, Groucho-related protein 4, KIAA1261, Transducin-like enhancer protein 4
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分子量
- approx. 83 kDa
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基因ID
- 7091
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NCBI登录号
- NP_008936
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UniProt
- Q04727
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途径
- WNT signaling
抗原
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