XPA 抗体
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北京 101111
Quick Overview for XPA 抗体 (ABIN271978)
抗原
See all XPA 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of XPA protein. (region surrounding His244)
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交叉反应 （详细）
- Species reactivity (tested):Human and Mouse.
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纯化方法
- Affinity Chromatography using epitope-specific immunogen.
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anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (Center) antibody
XPA 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 221-250), (C-Term) antibodyXPA 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB23644 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 185-213), (C-Term) antibodyXPA 适用: 人 WB 宿主: 兔 Polyclonal RB33699 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (Internal Region) antibodyXPA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 211-260) antibodyXPA 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-50) antibodyXPA 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term) antibodyXPA 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/5000approx. 1/10000. Western blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))
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别名
- XPA / XPAC
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背景
- Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer due to deficiencies in the DNA repair enzymes. The most frequent mutations are found in the XP genes of group A through G and group V, which encode nucleotide excision repair proteins. The XPA gene encodes a 31 kDa zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair. The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription, and the XPG gene product is an endonuclease that cuts on the 3' side of a DNA lesion during nucleotide excision repair. Molecular defects in the XP variant (XPV) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.Synonyms: DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein
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分子量
- approx. 33, 40 kDa
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基因ID
- 7507
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NCBI登录号
- NP_000371
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UniProt
- P23025
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途径
- DNA Damage Repair
抗原
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