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ErbB2/Her2 抗体 (AA 676-1255)

Name: ErbB2/Her2 抗体 (AA 676-1255)
SKU: ABIN2717953
Availability: OutOfStock

This anti-ErbB2/Her2 antibody is a 小鼠单克隆 antibody detecting ErbB2/Her2 in WB, IHC, IF 和 FACS. Suitable for 人. This Primary Antibody has been cited in 2+ publications.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ERBB2 (Right lane) cDNA for 48 hrs and lysed. (ErbB2/Her2 抗体 (AA 676-1255))

Anti-ERBB2 mouse monoclonal antibody (ABIN2454964) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ERBB2 (RC212583). (ErbB2/Her2 抗体 (AA 676-1255))

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ERBB2 mouse monoclonal antibody. (ErbB2/Her2 抗体 (AA 676-1255))

IHC

3 images

(2 references)

产品编号 ABIN2717953

发货至: 中国

Quick Overview for ErbB2/Her2 抗体 (AA 676-1255) (ABIN2717953)

抗原

See all ErbB2/Her2 抗体

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This ErbB2/Her2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

克隆位点

4F10

Discover our top product ErbB2/Her2 Primary Antibody

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AA 676-1255

产品特性

Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1

纯化方法

Purified from mouse ascites fluids by affinity chromatography

免疫原

Human recombinant protein fragment corresponding to amino acids 676-1255 of human ERBB2(NP_004439) produced in HEK293T cell.

亚型

IgG2a
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-372) antibody
ErbB2/Her2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠, 犬, 猴, 马, Pig, 兔, Cow, Hamster, Avian, Cat, 小鸡, 驴, 山羊, 豚鼠, 绵羊 WB 宿主: 山羊 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibody
ErbB2/Her2 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3B1 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1248) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1112) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr877) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERBB2-3078 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERBB2-2452 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibody
ErbB2/Her2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4E1 unconjugated

应用备注

WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100,

说明

The concentration of the product may vary between diferrent lots.

限制

仅限研究用
状态

Liquid

浓度

0.5-1.0 mg/mL

缓冲液

PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C
Choi, de Poot, Lee, Kim, Han, Kim, Finley, Lee: "Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation." in: Nature communications, Vol. 7, pp. 10963, (2016) (PubMed).

Bian, Lin, Wu, Cui, Qi, Li, Su: "Metaplastic carcinoma of the breast: Imaging and pathological features." in: Oncology letters, Vol. 12, Issue 5, pp. 3975-3980, (2016) (PubMed).
抗原

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

别名

ERBB2

背景

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

分子量

137.7 kDa

基因ID

2064

NCBI登录号

NM_004448

HGNC

2064

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development