CTNNB1 抗体
Quick Overview for CTNNB1 抗体 (ABIN2717124)
抗原
See all CTNNB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- Homo sapiens catenin (cadherin-associated protein), beta 1, 88 kDa (CTNNB1), transcript variant 1
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纯化方法
- Purified from mouse ascites fluids by affinity chromatography
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免疫原
- Full length human recombinant protein of human CTNNB1 (NP_001895) produced in HEK293T cell.
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亚型
- IgG2a
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应用备注
- WB 1:2000, IHC 1:150, FLOW 1:100,
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说明
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The concentration of the product may vary between diferrent lots.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5-1.0 mg/mL
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缓冲液
- PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
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别名
- CTNNB1
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背景
- The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
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分子量
- 85.3 kDa
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基因ID
- 1499
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NCBI登录号
- NM_001904
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HGNC
- 1499
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途径
- WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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