PTCRA 抗体
Cited in 6+ publications. This anti-PTCRA antibody is a 小鼠 单克隆 antibody detecting PTCRA in FACS 和 IP. Suitable for 小鼠.
(6 references)
产品编号 ABIN2689882
发货至:
中国
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Quick Overview for PTCRA 抗体 (ABIN2689882)
抗原
See all PTCRA 抗体
PTCRA
(Pre T-Cell Antigen Receptor alpha (PTCRA))
适用
小鼠
宿主
小鼠
克隆类型
单克隆
标记
This PTCRA antibody is un-conjugated
应用范围
Flow Cytometry (FACS), Immunoprecipitation (IP)
克隆位点
2F5
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产品特性
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At very early stages in the intrathymic differentiation of T lymphocytes which will bear αβ T Cell Receptors (TCR), the TCR β chain forms a heterodimer with the pre-TCR α chain (pTα) to form the pre-TCR. This pre-TCR associates with the signal-transducing CD3 complex and controls the survival and proliferation of CD4- CD8- (DN) thymocytes, plays a role in allelic exclusion of the TCR β chain, directly or indirectly regulates TCR δ chain expression, and is eventually replaced by the TCR α chain as thymocytes mature. The 2F5 antibody reacts with the PTα on the surface of CD44- CD25-/lo DN thymocytes.
BD Pharmingen™ Purified Mouse Anti-Mouse Pre-T Cell Receptor α Chain - Purified - Clone 2F5 - Isotype Mouse IgG1, κ - Reactivity Ms - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Recombinant extracellular (Ig-like) domain of pTalpha
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亚型
- IgG1 kappa
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anti-Pre T-Cell Antigen Receptor alpha (PTCRA) (AA 197-225), (C-Term) antibody
PTCRA 适用: 人 WB 宿主: 兔 Polyclonal RB39212 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex." in: The Journal of experimental medicine, Vol. 190, Issue 1, pp. 141-4, (1999) (PubMed).
: "Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein." in: The Journal of experimental medicine, Vol. 190, Issue 8, pp. 1093-102, (1999) (PubMed).
: "Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?" in: Seminars in immunology, Vol. 11, Issue 4, pp. 251-62, (1999) (PubMed).
: "Pleiotropic changes controlled by the pre-T-cell receptor." in: Current opinion in immunology, Vol. 11, Issue 2, pp. 135-42, (1999) (PubMed).
: "On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment." in: Immunity, Vol. 9, Issue 5, pp. 649-55, (1998) (PubMed).
: "Structure and function of the pre-T cell receptor." in: Annual review of immunology, Vol. 15, pp. 433-52, (1997) (PubMed).
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: "Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex." in: The Journal of experimental medicine, Vol. 190, Issue 1, pp. 141-4, (1999) (PubMed).
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- PTCRA (Pre T-Cell Antigen Receptor alpha (PTCRA))
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别名
- Pre-T Cell Receptor alpha Chain
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背景
- Synonyms: pTα
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途径
- Cancer Immune Checkpoints
抗原
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