(6 references)-
- 抗原
- HLA-DM (MHC Class II HLA-DM (HLA-DM))
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HLA-DM antibody is un-conjugated
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应用范围
- Intracellular Staining (ICS)
- 品牌
- BD Pharmingen™
- 产品特性
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Reacts with human leukocyte antigen-DM (HLA-DM), a non-classical MHC class II molecule expressed in the cytoplasm of antigen presenting cells (APC). HLA-DM is composed of alpha and beta subunits which form a similar structure as the classical class II molecules. HLA-DM catalyzes the dissociation of CLIP from MHC class II-CLIP complexes in vitro and facilitates the binding of antigenic peptides. It also prevents self-antigens from becoming stably complexed with class II molecules and being presented to T cells. Profile of intracellular staining of peripheral blood lymphocytes analyzed on a FACScan . Profile of intracellular staining of peripheral blood monocytes analyzed on a FACScan .
BD Pharmingen™ Purified Mouse Anti-Human HLA-DM - Purified - Clone MaP.DM1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 克隆位点
- MaP-DM1
- 亚型
- IgG1 kappa
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anti-MHC Class II HLA-DM (HLA-DM) (AA 101-200) antibody
HLA-DM 适用: 小鼠 ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules." in: The Journal of experimental medicine, Vol. 184, Issue 6, pp. 2153-65, (1997) (PubMed).
: "How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?" in: Immunology today, Vol. 18, Issue 2, pp. 77-82, (1997) (PubMed).
: "HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading." in: Cell, Vol. 82, Issue 1, pp. 155-65, (1995) (PubMed).
: "Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells." in: Immunity, Vol. 1, Issue 7, pp. 595-606, (1995) (PubMed).
: "Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines." in: The Journal of cell biology, Vol. 125, Issue 6, pp. 1225-37, (1994) (PubMed).
: "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides." in: Nature, Vol. 360, Issue 6403, pp. 474-7, (1992) (PubMed).
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: "HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules." in: The Journal of experimental medicine, Vol. 184, Issue 6, pp. 2153-65, (1997) (PubMed).
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- 抗原
- HLA-DM (MHC Class II HLA-DM (HLA-DM))
- 别名
- HLA-DM
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