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FOXP3 抗体

FOXP3 适用: 人, Baboon, Cynomolgus, 猕猴 WB, IHC, ICS 宿主: 小鼠 Monoclonal 259D-C7 unconjugated
产品编号 ABIN2689510
发货至: 中国
  • 抗原 See all FOXP3 抗体
    FOXP3 (Forkhead Box P3 (FOXP3))
    适用
    • 155
    • 113
    • 46
    • 25
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    人, Baboon, Cynomolgus, 猕猴
    宿主
    • 116
    • 58
    • 11
    • 2
    小鼠
    克隆类型
    • 116
    • 71
    单克隆
    标记
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    This FOXP3 antibody is un-conjugated
    应用范围
    • 133
    • 83
    • 70
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    • 27
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    Western Blotting (WB), Immunohistochemistry (IHC), Intracellular Staining (ICS)
    品牌
    BD Pharmingen™
    产品特性
    The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells. Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive. Approximately 5-10 % of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells. To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice. The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon. Flow cytometric analysis of Purified anti-Human FoxP3 on resting PBMC. Human PBMC were fixed and permeabilized using working solutions of FoxP3 Buffers A and C (Cat. No. 560098. see Recommended Assay Procedure), Intracellular staining with Purified Mouse anti-Human FoxP3 (clone 259D/C7, Cat. No. 560044) was followed by secondary staining with APC Rat anti-Mouse IgG1 (

    BD Pharmingen™ Purified Mouse anti-Human FoxP3 - Purified - Clone 259D/C7 - Isotype Mouse IgG1 - Reactivity Hu, Bab, Cyno, Rhe - 0.1 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    FoxP3 recombinant protein
    克隆位点
    259D-C7
    亚型
    IgG1
    Top Product
    Discover our top product FOXP3 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Roncador, Brown, Maestre, Hue, Martínez-Torrecuadrada, Ling, Pratap, Toms, Fox, Cerundolo, Powrie, Banham: "Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level." in: European journal of immunology, Vol. 35, Issue 6, pp. 1681-91, (2005) (PubMed).

    Brunkow, Jeffery, Hjerrild, Paeper, Clark, Yasayko, Wilkinson, Galas, Ziegler, Ramsdell: "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse." in: Nature genetics, Vol. 27, Issue 1, pp. 68-73, (2001) (PubMed).

    Wildin, Ramsdell, Peake, Faravelli, Casanova, Buist, Levy-Lahad, Mazzella, Goulet, Perroni, Bricarelli, Byrne, McEuen, Proll, Appleby, Brunkow: "X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy." in: Nature genetics, Vol. 27, Issue 1, pp. 18-20, (2001) (PubMed).

  • 抗原
    FOXP3 (Forkhead Box P3 (FOXP3))
    别名
    FoxP3 (FOXP3 产品)
    别名
    foxp3 antibody, FOXP3 antibody, AIID antibody, DIETER antibody, IPEX antibody, PIDX antibody, XPID antibody, JM2 antibody, scurfin antibody, sf antibody, RGD1562112 antibody, forkhead box P3 antibody, forkhead box P3a antibody, forkhead box P3 L homeolog antibody, FOXP3 antibody, foxp3a antibody, foxp3 antibody, foxp3.L antibody, Foxp3 antibody
    背景
    Synonyms: Scurfin, IPEX, JM2
    途径
    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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