Disialoganglioside 2 (GD2) 抗体
This 小鼠 单克隆 antibody specifically detects Disialoganglioside 2 in FACS, CyTox, IHC (fro) 和 IF. It exhibits reactivity toward 人 和 小鼠. It has been mentioned in 5+ publications
(5 references)
产品编号 ABIN2689490
发货至:
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Quick Overview for Disialoganglioside 2 (GD2) 抗体 (ABIN2689490)
抗原
Disialoganglioside 2 (GD2)
适用
人, 小鼠
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Flow Cytometry (FACS), Cytotoxicity Test (CyTox), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
克隆位点
14-G2a
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产品特性
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Gangliosides are sialic-acid bearing glycolipids that are expressed on the surface of all mammalian cells, and are likely involved in mediating cell-substratum interactions. They are important target antigens for antibody dependent cellular cytotoxicity (ADCC) of human melanoma and neuroblastoma cells. Human melanoma cells produce gangliosides, designated as GD2 and GD3 which are deposited in the subtratum-attached material, and may play a significant role in the melanoma metastatic phenotype.
BD Pharmingen™ Purified Mouse Anti-Human Disialoganglioside GD2 - Purified - Clone 14.G2a - Isotype Mouse IgG2a - Reactivity Hu, Ms - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- LAN-1 human neuroblastoma cells
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "A phase I/IB trial of murine monoclonal anti-GD2 antibody 14.G2a plus interleukin-2 in children with refractory neuroblastoma: a report of the Children's Cancer Group." in: Cancer, Vol. 80, Issue 2, pp. 317-33, (1997) (PubMed).
: "Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins." in: The Journal of cell biology, Vol. 102, Issue 3, pp. 688-96, (1986) (PubMed).
: "Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis." in: Cancer research, Vol. 46, Issue 10, pp. 5112-8, (1986) (PubMed).
: "Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 5155-9, (1985) (PubMed).
: "Tumor-associated carbohydrate antigens." in: Annual review of immunology, Vol. 2, pp. 103-26, (1985) (PubMed).
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- Disialoganglioside 2 (GD2)
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别名
- Disialoganglioside GD2
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背景
- Synonyms: GD2
抗原
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