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CD80 抗体

Name: CD80 抗体
SKU: ABIN2689405
Availability: OutOfStock

CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal BB1 unconjugated

(3 references)

产品编号 ABIN2689405

发货至: 中国

Datasheet as PDF

抗原 See all CD80 抗体

CD80
适用
132

110

43

6

3

3

1

1

1
人
宿主
88

63

24

21

15

1

1
小鼠
Compatible Secondaries
克隆类型
133

77

2
单克隆
标记
87

18

17

16

13

6

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This CD80 antibody is un-conjugated
应用范围
127

92

68

37

29

19

14

13

13

13

12

11

9

4

2

2

2

2

1

1

1

1

1

1
Flow Cytometry (FACS)

品牌

BD Pharmingen™

产品特性

Reacts with a 60 kD transmembrane glycoprotein which was clustered as CD80 in the Fifth International Workshop on Human Differentiation Antigens. There have been several recent studies reporting discrepancies in the expression and function of CD80 when the BB1 clone is used compared to other anti-CD80 monoclonals (e.g., L307.4). Caution should therefore be used in the interpretation of data generated using BB1, as reports indicate that BB1 may recognize, in addition to CD80, CD74 and even possibly another as yet undefined molecule. CD80, a member of the Ig supergene family, is expressed on activated B cells, macrophages, and dendritic cells. It is the ligand for two molecules expressed on T cells: CD28 and CD152 (CTLA-4). CD80 is also expressed in activated CD4+ and CD8+ T cells, appearing late after activation, suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway. The binding of CD28 Molecule by CD28 mAb or by CD80 antigen results in T-cell activation and a signal for IL-2 production. Profile of RAJI cells analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD80 - Purified - Clone BB1 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

克隆位点

BB1

亚型

IgM kappa

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CD80 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

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CD80 适用: 小鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated

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CD80 适用: 小鼠, 犬 FACS, IP, IHC (fro) 宿主: Armenian Hamster Monoclonal 16-10A1 unconjugated

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CD80 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal MEM-233 unconjugated

anti-CD80 (CD80) (Extracellular Domain) antibody (FITC)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 FITC

anti-CD80 (CD80) (Extracellular Domain) antibody (PE)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 PE

anti-CD80 (CD80) (Extracellular Domain) antibody (APC)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 APC

anti-CD80 (CD80) (Extracellular Domain) antibody (PerCP)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 PerCP

anti-CD80 (CD80) antibody
CD80 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2A2 unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

Aqueous buffered solution containing ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C.
Azuma, Yssel, Phillips, Spits, Lanier: "Functional expression of B7/BB1 on activated T lymphocytes." in: The Journal of experimental medicine, Vol. 177, Issue 3, pp. 845-50, (1993) (PubMed).

Schwartz: "Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy." in: Cell, Vol. 71, Issue 7, pp. 1065-8, (1993) (PubMed).

Koulova, Clark, Shu, Dupont: "The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells." in: The Journal of experimental medicine, Vol. 173, Issue 3, pp. 759-62, (1991) (PubMed).
抗原

CD80

别名

CD80 (CD80 产品)

别名

B7 antibody, B7-1 antibody, B7.1 antibody, BB1 antibody, CD28LG antibody, CD28LG1 antibody, LAB7 antibody, B71 antibody, Cd28l antibody, Ly-53 antibody, Ly53 antibody, MIC17 antibody, TSA1 antibody, CD80 molecule antibody, Cd80 molecule antibody, CD80 antigen antibody, CD80 antibody, Cd80 antibody

背景

Synonyms: B7-1

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints