CD79b 抗体
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北京 101111
Quick Overview for CD79b 抗体 (ABIN2689398)
抗原
See all CD79b (CD79B) 抗体适用
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克隆类型
标记
应用范围
克隆位点
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产品特性
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The HM79b antibody reacts with an extracellular epitope of Ig β chain (Igβ or CD79b), a 35-40- kDa transmembrane protein which forms an 80-90- kDa disulfide-linked heterodimer with Ig α chain (Igα or CD79a, 30-35 kDa). On mature B lymphocytes, the CD79a/CD79b heterodimers are non-covalently associated with surface IgM to form the B-cell receptor complex (BCR). The presence of CD79a/CD79b is necessary for surface expression of the BCR and signal transduction via the BCR in B lymphocytes and pre-B cells. It was recently reported that CD79b may be expressed on the cell surface preceding the appearance of surface IgM during B-lymphocyte development. At this pro-B-cell stage, CD79b participates in signal transduction involved in the regulation of B-cell development. It should be noted that multi-parameter flow cytometric analyses of bone marrow suspensions performed have been unable to detect surface staining by HM79b mAb on CD45R/B220+ IgM- cells. Two-color analysis of the expression of CD79b on mouse bone marrow cells. A single-cell suspension of BALB/c bone marrow was simultaneously stained with FITC-conjugated anti-mouse CD45R/B220 RA3-6B2 (Cat. No. 553087/553088) and purified HM79b monoclonal antibodies, followed by PE-conjugated anti-hamster IgG cocktail (Cat. No. 554056). Flow cytometry was performed on a BD FACSCalibur™ flow cytometry system.
BD Pharmingen™ Purified Hamster Anti-Mouse CD79b - Purified - Clone HM79b (also known as HM79-16) - Isotype Armenian Hamster IgG2, λ1 - Reactivity Ms - 0.5 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse B lymphoma, WEHI-123
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亚型
- IgG2 lambda
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anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-159) antibody
CD79B 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 1-229) antibodyCD79B 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 4E10-2A10 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (C-Term) antibodyCD79B 适用: 人 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal B29-123 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibody (FITC)CD79B 适用: 人 FACS 宿主: 小鼠 Monoclonal CB3-1 FITC
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibody (PE)CD79B 适用: 人 FACS 宿主: 小鼠 Monoclonal CB3-1 PE
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-229) antibodyCD79B 适用: 人, 小鼠, 大鼠 WB, FACS, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 WB, FACS, IP, IHC (p) 宿主: 小鼠 Monoclonal CB3-1 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 30-160) antibodyCD79B 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2G3C1 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB8065 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain." in: International immunology, Vol. 9, Issue 11, pp. 1767-72, (1998) (PubMed).
: "The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation." in: Immunity, Vol. 7, Issue 4, pp. 559-70, (1997) (PubMed).
: "Regulation of an early developmental checkpoint in the B cell pathway by Ig beta." in: Science (New York, N.Y.), Vol. 272, Issue 5260, pp. 411-4, (1996) (PubMed).
: "The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion." in: The Journal of experimental medicine, Vol. 182, Issue 5, pp. 1389-94, (1995) (PubMed).
: "The role of Ig beta in precursor B cell transition and allelic exclusion." in: Science (New York, N.Y.), Vol. 268, Issue 5209, pp. 408-11, (1995) (PubMed).
: "The B-cell antigen receptor complex: structure and signal transduction." in: Immunology today, Vol. 15, Issue 9, pp. 393-9, (1994) (PubMed).
: "Antigen receptors on B lymphocytes." in: Annual review of immunology, Vol. 10, pp. 97-121, (1992) (PubMed).
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: "CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain." in: International immunology, Vol. 9, Issue 11, pp. 1767-72, (1998) (PubMed).
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- CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
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别名
- CD79b
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背景
- Synonyms: Igβ
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途径
- BCR Signaling
抗原
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