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Transferrin Receptor 抗体

TFRC 适用: 小鼠 FACS, IF, IHC (fro), IHC (p) 宿主: 大鼠 Monoclonal C2 unconjugated
产品编号 ABIN2689385
发货至: 中国
  • 抗原 See all Transferrin Receptor (TFRC) 抗体
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    适用
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    大鼠
    克隆类型
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    单克隆
    标记
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    This Transferrin Receptor antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    品牌
    BD Pharmingen™
    产品特性
    The C2 antibody reacts with the transferrin receptor CD71, a disulfide-linked homodimer of 95- kDa subunits. CD71 mediates one of the cellular mechanisms for iron uptake, and its expression is regulated according to the cell's iron requirements. It is expressed at high levels on developing erythroid cells, and it is upregulated after mitogenic activation of B or T lymphocytes. C2 mAb selectivity inhibits some types of T- and B-cell activation by down-regulation of transferrin receptor expression, but it does not block binding of transferrin. Although the isotype of C2 mAb was originally reported to be Rat IgG2a, further investigations have demonstrated that it is Rat IgG1, κ.

    BD Pharmingen™ Purified Rat Anti-Mouse CD71 - Purified - Clone C2 (also known as C2F2) - Isotype Rat IgG1, κ - Reactivity Ms - 0.5 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse cell line
    克隆位点
    C2
    亚型
    IgG1 kappa
    Top Product
    Discover our top product TFRC Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Lok, Loh: "Regulation of transferrin function and expression: review and update." in: Biological signals and receptors, Vol. 7, Issue 3, pp. 157-78, (1998) (PubMed).

    Fujimoto: "GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after crosslinking." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 44, Issue 8, pp. 929-41, (1996) (PubMed).

    Kemp, Thorson, Gomez, Smith, Cowdery, Ballas: "Inhibition of lymphocyte activation with anti-transferrin receptor Mabs: a comparison of three reagents and further studies of their range of effects and mechanism of action." in: Cellular immunology, Vol. 122, Issue 1, pp. 218-30, (1989) (PubMed).

  • 抗原
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    别名
    CD71 (TFRC 产品)
    别名
    Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody
    背景
    Synonyms: Transferrin Receptor
    途径
    Transition Metal Ion Homeostasis
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