CD36 抗体
Quick Overview for CD36 抗体 (ABIN2689209)
抗原
See all CD36 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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品牌
- BD Pharmingen™
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产品特性
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The CRF D-2712 antibody reacts with mouse and rat CD36, an 88- kDa glycoprotein member of the class B scavenger receptor family. CD36 is a multifunctional receptor which has a variety of ligands and is expressed on many cell types. Consequently, it is known by several names, including macrophage scavenger receptor, platelet glycoprotein IV, and fatty acid translocase. Cells which express CD36 include platelets, megakaryocytes, monocytes/macrophages, dendritic cells, erythroid precursors, microvascular endothelia, skeletal, cardiac, and smooth muscle cells, adipocytes, and epithelia of retina, breast, and intestine. Therefore, we would not expect to detect CD36 expression by flow cytometry of leukocytes isolated from naive peripheral lymphoid tissues. This multi-ligand receptor functions in the clearance of apoptotic cells and abnormal erythrocytes (in malaria and sickle-cell anemia), the transport of long-chain fatty acids and oxidized low-density lipoproteins, the regulation of angiogenesis by mediating the effects of thrombospondin-1, and the mediation of coronary vasoconstriction. Cross-linking of cell-surface CD36 with plate-bound CRF D-2712 mAb promotes internalization of photoreceptor outer segment fragments by cultured retinal pigment epithelium.
BD Pharmingen™ Purified Mouse Anti-Mouse CD36 - Purified - Clone CRF D-2712 - Isotype Mouse IgA, κ - Reactivity Ms, Rat - 0.5 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Recombinant mouse CD36
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亚型
- IgA kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart." in: Circulation research, Vol. 90, Issue 8, pp. 844-9, (2002) (PubMed).
: "CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism." in: The Journal of clinical investigation, Vol. 108, Issue 6, pp. 785-91, (2001) (PubMed).
: "Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium." in: The Journal of experimental medicine, Vol. 194, Issue 9, pp. 1289-98, (2001) (PubMed).
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: "CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart." in: Circulation research, Vol. 90, Issue 8, pp. 844-9, (2002) (PubMed).
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- CD36
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别名
- CD36
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背景
- Synonyms: Scavenger Receptor
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途径
- TLR signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteins
抗原
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