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EZH2 抗体 (AA 1-370)

Name: EZH2 抗体 (AA 1-370)
SKU: ABIN7938125
Availability: OutOfStock

Cited in 9+ publications. The 兔多克隆 anti-EZH2 antibody (ABIN7938125) specifically detects EZH2 in IP, ChIP, ChIP-seq 和 CUT&RUN. The antibody is reactive with 人和小鼠 samples.

ChIP

ChIP-seq

2 images

(9 references)

产品编号 ABIN7938125

发货至: 中国

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Quick Overview for EZH2 抗体 (AA 1-370) (ABIN7938125)

抗原

See all EZH2 抗体

EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This EZH2 antibody is un-conjugated

应用范围

Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq), Cleavage Under Targets and Release Using Nuclease (CUT&RUN)

Discover our top product EZH2 Primary Antibody

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AA 1-370

原理

EZH2 antibody (pAb)

纯化方法

Unpurified

免疫原

This EZH2 antibody was raised against a recombinant fusion protein corresponding to amino acids 1-370 of mouse EZH2.
anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 144CT2-1-1-5 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-296), (N-Term) antibody
EZH2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23144 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 51-285) antibody
EZH2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-194) antibody
EZH2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6G4F4 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 410-440) antibody
EZH2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2921 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人, 小鼠 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-154) antibody
EZH2 适用: 人, 小鼠 WB, IHC, ICC, FACS, IP 宿主: 兔 Monoclonal BLR338M unconjugated Recombinant Antibody

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 696-746) antibody
EZH2 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
KD Validated EZH2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB7200 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

ChIP-Seq: 5 µL each CUT&RUN: 1 µL per 50 µL reaction This antibody has not been validated in WB, but a WB-validated antibody is available for this target: 39933. For EZH2, we also offer AbFlex EZH2 Recombinant Antibody (rAb). For details, see Catalog No. 91159.

限制

仅限研究用
状态

Liquid

缓冲液

Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

储存条件

-20 °C

储存方法

Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

有效期

24 months
LaFave, Béguelin, Koche, Teater, Spitzer, Chramiec, Papalexi, Keller, Hricik, Konstantinoff, Micol, Durham, Knutson, Campbell, Blum, Shi, Doud, Krivtsov, Chung, Khodos, de Stanchina, Ouerfelli et al.: "Loss of BAP1 function leads to EZH2-dependent transformation. ..." in: Nature medicine, Vol. 21, Issue 11, pp. 1344-9, (2015) (PubMed).

Knutson, Kawano, Minoshima, Warholic, Huang, Xiao, Kadowaki, Uesugi, Kuznetsov, Kumar, Wigle, Klaus, Allain, Raimondi, Waters, Smith, Porter-Scott, Chesworth, Moyer, Copeland, Richon, Uenaka, Pollock et al.: "Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. ..." in: Molecular cancer therapeutics, Vol. 13, Issue 4, pp. 842-54, (2014) (PubMed).

Inoue, Kitaura, Togami, Nishimura, Enomoto, Uchida, Kagiyama, Kawabata, Nakahara, Izawa, Oki, Maehara, Isobe, Tsuchiya, Harada, Harada, Ochiya, Aburatani, Kimura, Thol, Heuser, Levine, Abdel-Wahab et al.: "Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. ..." in: The Journal of clinical investigation, Vol. 123, Issue 11, pp. 4627-40, (2014) (PubMed).

Kumar, Duester: "Retinoic acid controls body axis extension by directly repressing Fgf8 transcription." in: Development (Cambridge, England), Vol. 141, Issue 15, pp. 2972-7, (2014) (PubMed).

Tong, He, Xie, Mochizuki, Liu, Mochizuki, Meng, Sun, Zhang, Guo, Hexner, Zhang: "Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 5012-22, (2014) (PubMed).

Bender, Tang, Lindroth, Hovestadt, Jones, Kool, Zapatka, Northcott, Sturm, Wang, Radlwimmer, Højfeldt, Truffaux, Castel, Schubert, Ryzhova, Seker-Cin, Gronych, Johann, Stark, Meyer, Milde, Schuhmann et al.: "Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. ..." in: Cancer cell, Vol. 24, Issue 5, pp. 660-72, (2013) (PubMed).

Chng, Chang, Tan, Yang, Hong, Sng, Cheung: "A transcriptional repressor co-regulatory network governing androgen response in prostate cancers." in: The EMBO journal, Vol. 31, Issue 12, pp. 2810-23, (2012) (PubMed).

Abdel-Wahab, Adli, LaFave, Gao, Hricik, Shih, Pandey, Patel, Chung, Koche, Perna, Zhao, Taylor, Park, Carroll, Melnick, Nimer, Jaffe, Aifantis, Bernstein, Levine: "ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression." in: Cancer cell, Vol. 22, Issue 2, pp. 180-93, (2012) (PubMed).

Bredfeldt, Greathouse, Safe, Hung, Bedford, Walker: "Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 5, pp. 993-1006, (2010) (PubMed).
抗原

EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

别名

EZH2

背景

EZH2 - (Enhancer of Zeste homolog 2) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers.

分子量

96 kDa

基因ID

2146

NCBI登录号

NP_031997

途径

Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation