EZH2 抗体 (AA 353-451)
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北京 101111
Quick Overview for EZH2 抗体 (AA 353-451) (ABIN2668955)
抗原
See all EZH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 353-451
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原理
- EZH2 antibody (mAb) (Clone AC22)
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纯化方法
- Protein A Chromatography
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免疫原
- This EZH2 antibody was raised against a recombinant protein corresponding to amino acids 353-451 of human EZH2.
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亚型
- IgG2a
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anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 144CT2-1-1-5 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-296), (N-Term) antibodyEZH2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23144 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 51-285) antibodyEZH2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-194) antibodyEZH2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6G4F4 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 410-440) antibodyEZH2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2921 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-154) antibodyEZH2 适用: 人, 小鼠 WB, IHC, ICC, FACS, IP 宿主: 兔 Monoclonal BLR338M unconjugated Recombinant Antibody
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 696-746) antibodyEZH2 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyKD Validated EZH2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB7200 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- ChIP: 1 - 3 μg per ChIP CUT&RUN: 1 µL per 50 µL reaction This antibody has been published, but not validated by Active Motif, for Western blot. For an antibody we have tested in use in Western blotting, see Catalog No. 39933. For EZH2, we also offer an AbFlex EZH2 Recombinant Antibody (rAb). For details, see Catalog No. 91159.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection." in: PLoS pathogens, Vol. 12, Issue 9, pp. e1005878, (2016) (PubMed).
: "The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4." in: Nature immunology, Vol. 16, Issue 3, pp. 318-325, (2015) (PubMed).
: "Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome." in: PLoS ONE, Vol. 8, Issue 6, pp. e67217, (2013) (PubMed).
: "Cutting edge: Smad2 and Smad4 regulate TGF-β-mediated Il9 gene expression via EZH2 displacement." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 10, pp. 4908-12, (2013) (PubMed).
: "Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells." in: PLoS pathogens, Vol. 9, Issue 5, pp. e1003366, (2013) (PubMed).
: "Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program." in: The Journal of biological chemistry, Vol. 288, Issue 9, pp. 6238-47, (2013) (PubMed).
: "BZLF1 governs CpG-methylated chromatin of Epstein-Barr Virus reversing epigenetic repression." in: PLoS pathogens, Vol. 8, Issue 9, pp. e1002902, (2012) (PubMed).
: "Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells." in: Journal of virology, Vol. 86, Issue 9, pp. 4752-61, (2012) (PubMed).
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- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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别名
- EZH2
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背景
- EZH2 - (Enhancer of Zeste homolog 2, also designated Enx1 and SETDB1) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers.
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分子量
- 96 kDa
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基因ID
- 2146
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NCBI登录号
- NP_004447
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
-
