MALT1 抗体 (AA 701-808)
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Quick Overview for MALT1 抗体 (AA 701-808) (ABIN2668934)
抗原
See all MALT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 701-808
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原理
- MALT1 antibody (mAb)
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纯化方法
- Protein G Chromatography
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免疫原
- This MALT1 antibody was raised against a recombinant protein corresponding to amino acids 701-808 of mouse MALT1.
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亚型
- IgG
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应用备注
- WB: 0.5 - 2 μg/mL dilution
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))
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别名
- MALT1
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背景
- MALT1 enhances Bcl10-induced activation of NFkB and is also involved in nuclear export of Bcl10. MALT1 binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. MALT1-dependent Bcl10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. MALT1 was independently identified as a protein of 824 amino acids, and human MALT2 isoform b is an amino acid protein of 813 amino acids. MALT1 is thought to play a role in NFkB signaling by enhancing NFkB (NFkB p50 & NFkB p65) activation through interaction with Bcl10. Interaction between MALT1 and Bcl10 mediates IKK (IKKa, IKKb, IKKi/IKKe and IKKg) activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13.
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分子量
- 92 kDa
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基因ID
- 10892
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NCBI登录号
- NP_006776
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
抗原
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