Histone H4 抗体 (H4K31me1)
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Quick Overview for Histone H4 抗体 (H4K31me1) (ABIN2668878)
抗原
See all Histone H4 (HISTH4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- H4K31me1
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原理
- Histone H4K31me1 antibody (pAb)
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纯化方法
- Unpurified
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免疫原
- This Histone H4 monomethyl Lys31 antibody was raised against a peptide containing monomethyl Lys31 of human histone H4.
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应用备注
- WB: 1:500 - 1:2,000 dilution
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Chd5 orchestrates chromatin remodelling during sperm development." in: Nature communications, Vol. 5, pp. 3812, (2014) (PubMed).
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- Histone H4 (HISTH4)
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别名
- Histone H4
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背景
- Histone H4 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points, it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation, they play a major role in regulating gene expression. The methylation of histones can occur on two different residues: arginine or lysine. Changes in methylation of histone H2B may be involved in heat-shock mechanisms.
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分子量
- 8 kDa
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基因ID
- 121504
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NCBI登录号
- NP_778224
抗原
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